PMID- 23621986
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20240505
IS  - 1471-2466 (Electronic)
IS  - 1471-2466 (Linking)
VI  - 13
DP  - 2013 Apr 27
TI  - Dyspnea affective response: comparing COPD patients with healthy volunteers and 
      laboratory model with activities of daily living.
PG  - 27
LID - 10.1186/1471-2466-13-27 [doi]
AB  - BACKGROUND: Laboratory-induced dyspnea (breathing discomfort) in healthy subjects 
      is widely used to study perceptual mechanisms, yet the relationship between 
      laboratory-induced dyspnea in healthy volunteers and spontaneous dyspnea in 
      patients with chronic lung disease is not well established. We compared affective 
      responses to dyspnea 1) in COPD patients vs. healthy volunteers (HV) undergoing 
      the same laboratory stimulus; 2) in COPD during laboratory dyspnea vs. during 
      activities of daily living (ADL). METHODS: We induced moderate and high dyspnea 
      levels in 13 COPD patients and 12 HV by increasing end-tidal CO2 (PETCO2) during 
      restricted ventilation, evoking air hunger. We used the multidimensional dyspnea 
      profile (MDP) to measure intensity of sensory qualities (e.g., air hunger (AH) 
      and work/effort (W/E)) as well as immediate discomfort (A1) and secondary 
      emotions (A2). Ten of the COPD subjects also completed the MDP outside the 
      laboratory following dyspnea evoked by ADL. RESULTS: COPD patients and HV 
      reported similar levels of immediate discomfort relative to sensory intensity. 
      COPD patients and HV reported anxiety and frustration during laboratory-induced 
      dyspnea; variation among individuals far outweighed the small differences between 
      subject groups. COPD patients reported similar intensities of sensory qualities, 
      discomfort, and emotions during ADL vs. during moderate laboratory dyspnea. 
      Patients with COPD described limiting ADL to avoid greater dyspnea. CONCLUSIONS: 
      In this pilot study, we found no evidence that a history of COPD alters the 
      affective response to laboratory-induced dyspnea, and no difference in affective 
      response between dyspnea evoked by this laboratory model and dyspnea evoked by 
      ADL.
FAU - O'Donnell, Carl R
AU  - O'Donnell CR
AD  - Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess 
      Medical Center, Boston, MA, 02215, USA. codonne1@bidmc.harvard.edu
FAU - Schwartzstein, Richard M
AU  - Schwartzstein RM
FAU - Lansing, Robert W
AU  - Lansing RW
FAU - Guilfoyle, Tegan
AU  - Guilfoyle T
FAU - Elkin, Daniel
AU  - Elkin D
FAU - Banzett, Robert B
AU  - Banzett RB
LA  - eng
GR  - R01 NR010006/NR/NINR NIH HHS/United States
GR  - NR10006/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130427
PL  - England
TA  - BMC Pulm Med
JT  - BMC pulmonary medicine
JID - 100968563
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Activities of Daily Living/*psychology
MH  - Aged
MH  - Aged, 80 and over
MH  - Anxiety/epidemiology
MH  - Carbon Dioxide/adverse effects
MH  - Case-Control Studies
MH  - Dyspnea/chemically induced/*psychology
MH  - *Emotions
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Pulmonary Disease, Chronic Obstructive/*psychology
MH  - Tidal Volume
PMC - PMC3663820
EDAT- 2013/04/30 06:00
MHDA- 2014/01/31 06:00
PMCR- 2013/04/27
CRDT- 2013/04/30 06:00
PHST- 2012/11/09 00:00 [received]
PHST- 2013/04/17 00:00 [accepted]
PHST- 2013/04/30 06:00 [entrez]
PHST- 2013/04/30 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
PHST- 2013/04/27 00:00 [pmc-release]
AID - 1471-2466-13-27 [pii]
AID - 10.1186/1471-2466-13-27 [doi]
PST - epublish
SO  - BMC Pulm Med. 2013 Apr 27;13:27. doi: 10.1186/1471-2466-13-27.