PMID- 23622874
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20220318
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 120
IP  - 9
DP  - 2013 Sep
TI  - Evaluation of lamina cribrosa in pseudoexfoliation syndrome using spectral-domain 
      optical coherence tomography enhanced depth imaging.
PG  - 1798-803
LID - S0161-6420(13)00149-8 [pii]
LID - 10.1016/j.ophtha.2013.02.015 [doi]
AB  - PURPOSE: To evaluate the features of the lamina cribrosa (LC) in 
      pseudoexfoliation glaucoma (PXG) patients using enhanced depth imaging (EDI) of 
      spectral-domain optical coherence tomography (SD OCT). The results were compared 
      with those of patients with primary open-angle glaucoma (POAG). DESIGN: 
      Cross-sectional study. PARTICIPANTS: Patients with PXG (n = 21) and POAG (n = 35) 
      matched for age and visual field mean deviation (VF MD). METHODS: Participants 
      were imaged using SD OCT. Lamina cribrosa thickness (LT) and anterior lamina 
      cribrosa depth (ALD) were determined at 3 areas (mid superior, center, and mid 
      inferior) by 2 examiners using an EDI mode of the optic nerve head. MAIN OUTCOME 
      MEASURES: The LT and ALD were compared between PXG and POAG eyes. RESULTS: Mean +/- 
      standard deviation baseline untreated intraocular pressure was not significantly 
      different between the 2 groups (PXG, 18.3 +/- 8.2 mmHg; POAG, 15.3 +/- 3.4 mmHg; P = 
      0.310). The mean VF MD was -12.7 +/- 9.0 dB in the PXG group versus -11.6 +/- 9.1 dB 
      in the POAG group (P = 0.643). When compared with the POAG group, the PXG group 
      demonstrated a significantly thinner LT in all 3 areas and a thinner mean LT 
      (133.4 +/- 14.5 mum in the POAG group vs. 121.3 +/- 13.0 mum in the PXG group; 
      P<0.001). Anterior lamina cribrosa depth did not demonstrate a significant 
      difference in any of the 3 areas between both groups (mean ALD, 324.3 +/- 91.9 mum 
      in the POAG group vs. 358.7 +/- 142.7 mum in the PXG group; P = 0.470). Of 21 eyes 
      in the PXG group, 9 eyes demonstrated a unilateral clinical presentation. When we 
      compared the PXG eyes and the apparently normal-looking fellow eyes of those 9 
      eyes, neither the LT nor ALD demonstrated a significant difference (P = 0.223 and 
      P = 0.079, respectively). CONCLUSIONS: Eyes with PXG demonstrate a thinner LC 
      compared with POAG eyes at similar levels of glaucoma severity. FINANCIAL 
      DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any 
      materials discussed in this article.
CI  - Copyright (c) 2013 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Kim, Soa
AU  - Kim S
AD  - Department of Ophthalmology, College of Medicine, University of Ulsan, Asan 
      Medical Center, Seoul, Korea.
FAU - Sung, Kyung Rim
AU  - Sung KR
FAU - Lee, Jong Rak
AU  - Lee JR
FAU - Lee, Kyoung Sub
AU  - Lee KS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130425
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Exfoliation Syndrome/*diagnosis
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity
MH  - Visual Fields
EDAT- 2013/04/30 06:00
MHDA- 2013/11/20 06:00
CRDT- 2013/04/30 06:00
PHST- 2012/10/19 00:00 [received]
PHST- 2013/02/13 00:00 [revised]
PHST- 2013/02/13 00:00 [accepted]
PHST- 2013/04/30 06:00 [entrez]
PHST- 2013/04/30 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - S0161-6420(13)00149-8 [pii]
AID - 10.1016/j.ophtha.2013.02.015 [doi]
PST - ppublish
SO  - Ophthalmology. 2013 Sep;120(9):1798-803. doi: 10.1016/j.ophtha.2013.02.015. Epub 
      2013 Apr 25.