PMID- 23623815
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20191210
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1519
DP  - 2013 Jun 26
TI  - Region-specific expression of brain-derived neurotrophic factor splice variants 
      in morphine conditioned place preference in mice.
PG  - 53-62
LID - S0006-8993(13)00573-8 [pii]
LID - 10.1016/j.brainres.2013.04.031 [doi]
AB  - It is well established that brain-derived neurotrophic factor (BDNF) plays a 
      pivotal role in brain plasticity-related processes, such as learning, memory and 
      drug addiction. However, changes in expression of BDNF splice variants after 
      acquisition, extinction and reinstatement of cue-elicited morphine seeking 
      behavior have not yet been investigated. Real-time PCR was used to assess BDNF 
      splice variants (I, II, IV and VI) in various brain regions during acquisition, 
      extinction and reinstatement of morphine-conditioned place preference (CPP) in 
      mice. Repeated morphine injections (10mg/kg, i.p.) increased expression of BDNF 
      splice variants II, IV and VI in the hippocampus, caudate putamen (CPu) and 
      nucleus accumbens (NAcc). Levels of BDNF splice variants decreased after 
      extinction training and continued to decrease during reinstatement induced by a 
      morphine priming injection (10mg/kg, i.p.). However, after reinstatement induced 
      by exposure to 6 min of forced swimming (FS), expression of BDNF splice variants 
      II, IV and VI was increased in the hippocampus, CPu, NAcc and prefrontal cortex 
      (PFC). After reinstatement induced by 40 min of restraint, expression of BDNF 
      splice variants was increased in PFC. These results show that exposure to either 
      morphine or acute stress can induce reinstatement of drug-seeking, but expression 
      of BDNF splice variants is differentially affected by chronic morphine and acute 
      stress. Furthermore, BDNF splice variants II, IV and VI may play a role in 
      learning and memory for morphine addiction in the hippocampus, CPu and NAcc.
CI  - Crown Copyright (c) 2013. Published by Elsevier B.V. All rights reserved.
FAU - Meng, Min
AU  - Meng M
AD  - Department of Oncology, First Affiliated Hospital of Medical School of Xi'an 
      Jiaotong University, 277# West YantaRoad, Xi'an 710061, PR China.
FAU - Zhao, Xinhan
AU  - Zhao X
FAU - Dang, Yonghui
AU  - Dang Y
FAU - Ma, Jingyuan
AU  - Ma J
FAU - Li, Lixu
AU  - Li L
FAU - Gu, Shanzhi
AU  - Gu S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130425
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Narcotics)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Conditioning, Operant/*drug effects
MH  - Drug-Seeking Behavior/drug effects/physiology
MH  - Extinction, Psychological/drug effects
MH  - Gene Expression Regulation/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Morphine/metabolism/*pharmacology
MH  - Narcotics/metabolism/*pharmacology
MH  - Protein Isoforms/genetics/metabolism
MH  - RNA, Messenger/metabolism
MH  - Reinforcement, Psychology
EDAT- 2013/04/30 06:00
MHDA- 2014/01/24 06:00
CRDT- 2013/04/30 06:00
PHST- 2012/12/21 00:00 [received]
PHST- 2013/03/25 00:00 [revised]
PHST- 2013/04/19 00:00 [accepted]
PHST- 2013/04/30 06:00 [entrez]
PHST- 2013/04/30 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
AID - S0006-8993(13)00573-8 [pii]
AID - 10.1016/j.brainres.2013.04.031 [doi]
PST - ppublish
SO  - Brain Res. 2013 Jun 26;1519:53-62. doi: 10.1016/j.brainres.2013.04.031. Epub 2013 
      Apr 25.