PMID- 23624487
OWN - NLM
STAT- MEDLINE
DCOM- 20131022
LR  - 20180816
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 99
IP  - 13
DP  - 2013 Jul
TI  - Smoking and obesity associated BDNF gene variance predicts total and 
      cardiovascular mortality in smokers.
PG  - 949-53
LID - 10.1136/heartjnl-2013-303634 [doi]
AB  - OBJECTIVE: The brain derived neurotrophic factor (BDNF) locus has been implicated 
      in psychiatric and substance related disorders. Recent genome-wide association 
      studies (GWAS) have shown strong associations between single nucleotide 
      polymorphisms in BDNF, smoking behaviour and high body mass index (BMI). Our aim 
      was to test whether genetic BDNF variation alters the risk of smoking related 
      morbidity and mortality. DESIGN: Cox proportional hazards models were used to 
      relate the BDNF rs4923461(A/G) polymorphisms to all-cause, cancer and 
      cardiovascular mortality and cardiovascular disease (CVD) incidence adjusted for 
      age, sex, BMI, and smoking quantity. SETTING: The Malmo Diet and Cancer Study 
      (MDCS), a population based prospective cohort study (n=30 447). PATIENTS: We 
      obtained complete data on 25 071 subjects, of whom 6507 were current smokers and 
      18 564 were non-smokers who underwent a baseline examination from 1991-1996. MAIN 
      OUTCOME MEASURES: During a mean follow-up time of 12 years, 1049 deaths (346 
      cardiovascular deaths and 492 cancer deaths) and 802 incident CVD events occurred 
      among current smokers. RESULTS: The major allele (A) of rs4923461 was 
      significantly associated with ever having smoked (p=0.03) and high BMI (p=0.001). 
      The A-allele was associated with risk of all-cause (HR=1.12, 95% CI 1.00 to 1.25; 
      p<0.05) and CVD (HR=1.23, 95% CI 1.01 to 1.49; p=0.04) mortality. There was no 
      significant association between the rs4923461 and cancer mortality or CVD 
      incidence. CONCLUSIONS: Our data suggest that smoking- and obesity-associated 
      variation of the BDNF gene affects the risk of death, especially due to 
      cardiovascular causes, in smokers. Determination of the BDNF genotype in smokers 
      may guide the need for smoking cessation interventions.
FAU - Hallden, Sara
AU  - Hallden S
AD  - Department of Clinical Sciences, Lund University, Clinical Research Center, 
      Entrance 72, Building 91, Floor 12, Malmo University Hospital, Malmo SE 205 02, 
      Sweden. sara.hallden@med.lu.se
FAU - Sjogren, Marketa
AU  - Sjogren M
FAU - Hedblad, Bo
AU  - Hedblad B
FAU - Engstrom, Gunnar
AU  - Engstrom G
FAU - Narkiewicz, Krzysztof
AU  - Narkiewicz K
FAU - Hoffmann, Michal
AU  - Hoffmann M
FAU - Wahlstrand, Bjorn
AU  - Wahlstrand B
FAU - Hedner, Thomas
AU  - Hedner T
FAU - Melander, Olle
AU  - Melander O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130427
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cardiovascular Diseases/*genetics/mortality/prevention & control
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Obesity/complications/*genetics/mortality
MH  - Odds Ratio
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Risk Reduction Behavior
MH  - Sex Factors
MH  - Smoking/adverse effects/*genetics/mortality
MH  - Smoking Cessation
MH  - Smoking Prevention
MH  - Sweden/epidemiology
MH  - Time Factors
EDAT- 2013/04/30 06:00
MHDA- 2013/10/23 06:00
CRDT- 2013/04/30 06:00
PHST- 2013/04/30 06:00 [entrez]
PHST- 2013/04/30 06:00 [pubmed]
PHST- 2013/10/23 06:00 [medline]
AID - heartjnl-2013-303634 [pii]
AID - 10.1136/heartjnl-2013-303634 [doi]
PST - ppublish
SO  - Heart. 2013 Jul;99(13):949-53. doi: 10.1136/heartjnl-2013-303634. Epub 2013 Apr 
      27.