PMID- 23624943
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20211021
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 38
IP  - 7
DP  - 2013 Jul
TI  - Prenatal stress produces social behavior deficits and alters the number of 
      oxytocin and vasopressin neurons in adult rats.
PG  - 1479-89
LID - 10.1007/s11064-013-1049-5 [doi]
AB  - The present study investigated the long-lasting effects of prenatal repeated 
      restraint stress on social behavior and anxiety, as well as its repercussions on 
      oxytocin (OT) and vasopressin (VP)-positive neurons of the paraventricular (PVN) 
      and supraoptic (SON) nuclei from stressed pups in adulthood. Female Wistar rats 
      were exposed to restraint stress in the last 7 days of pregnancy. At birth, pups 
      were cross-fostered and assigned to the following groups: prenatally non-stressed 
      offspring raised by prenatally non-stressed mothers (NS:NS), prenatally 
      non-stressed offspring raised by prenatally stressed mothers (S:NS), prenatally 
      stressed offspring raised by prenatally non-stressed mothers (NS:S), prenatally 
      stressed offspring raised by prenatally stressed mothers (S:S). As adults, male 
      prenatally stressed offspring raised both by stressed mothers (S:S group) and 
      non-stressed ones (NS:S group) showed impaired social memory and interaction. In 
      addition, when both adverse conditions coexisted (S:S group), increased 
      anxiety-like behavior and aggressiveness was observed in association with a 
      decrease in the number of OT-positive magnocellular neurons, VP-positive 
      magnocellular and parvocellular neurons of the PVN. The NS:S group exhibited a 
      reduction in the amount of VP-positive magnocellular neurons compared to the 
      S:NS. Thus, the social behavior deficits observed in the S:S and NS:S groups may 
      be only partially associated with these alterations to the peptidergic systems. 
      No changes were shown in the OT and VP cellular composition of the SON nucleus. 
      Nevertheless, it is clear that a special attention should be given to the 
      gestational period, since stressful events during this time may be related to the 
      emergence of behavioral impairments in adulthood.
FAU - de Souza, Marcelo Alves
AU  - de Souza MA
AD  - Programa de Pos-Graduacao em Fisiologia, Departamento de Fisiologia, Instituto de 
      Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Sarmento 
      Leite, 500, Porto Alegre, RS, CEP 90050-170, Brazil. tiflosoles@yahoo.com.br
FAU - Centenaro, Ligia Aline
AU  - Centenaro LA
FAU - Menegotto, Pamela Rossi
AU  - Menegotto PR
FAU - Henriques, Thiago Pereira
AU  - Henriques TP
FAU - Bonini, Juliana
AU  - Bonini J
FAU - Achaval, Matilde
AU  - Achaval M
FAU - Lucion, Aldo Bolten
AU  - Lucion AB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130430
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 11000-17-2 (Vasopressins)
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Female
MH  - Maze Learning
MH  - Neurons/*metabolism
MH  - Oxytocin/*metabolism
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
MH  - *Social Behavior
MH  - *Stress, Physiological
MH  - Vasopressins/*metabolism
EDAT- 2013/04/30 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/04/30 06:00
PHST- 2013/01/20 00:00 [received]
PHST- 2013/04/16 00:00 [accepted]
PHST- 2013/03/31 00:00 [revised]
PHST- 2013/04/30 06:00 [entrez]
PHST- 2013/04/30 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - 10.1007/s11064-013-1049-5 [doi]
PST - ppublish
SO  - Neurochem Res. 2013 Jul;38(7):1479-89. doi: 10.1007/s11064-013-1049-5. Epub 2013 
      Apr 30.