PMID- 23625314
OWN - NLM
STAT- MEDLINE
DCOM- 20140618
LR  - 20211021
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 48
IP  - 3
DP  - 2013 Dec
TI  - Autophagy modulation for Alzheimer's disease therapy.
PG  - 702-14
LID - 10.1007/s12035-013-8457-z [doi]
AB  - Autophagy is an essential and conserved lysosomal degradation pathway that 
      controls the quality of cytoplasm by eliminating the intracellular aggregated 
      proteins and damaged organelles. Autophagy works in mammalian target of rapamycin 
      (mTOR)-dependent pathway or mTOR-independent pathway to keep the neuronal 
      homeostasis. Mounting evidence has implicated the importance of defective 
      autophagy in the pathogenesis of aging and neurodegenerative diseases, especially 
      in Alzheimer's disease (AD). It has also demonstrated a neuroprotective role of 
      autophagy in mediating the degradation of amyloid beta and tau which are major 
      factors of AD. Amounts of molecules function in either mTOR-dependent pathway or 
      mTOR-independent pathway to induce autophagy, which maybe a potential treatment 
      for AD. In this review, we summarize the latest studies concerning the role of 
      autophagy in AD and explore autophagy modulation as a potential therapeutic 
      strategy for AD. However, to date, little of the researches on autophagy have 
      been performed to investigate the modulation in AD; more investigations need to 
      be confirmed in the future.
FAU - Zhu, Xi-Chen
AU  - Zhu XC
AD  - Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Yu, Jin-Tai
AU  - Yu JT
FAU - Jiang, Teng
AU  - Jiang T
FAU - Tan, Lan
AU  - Tan L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130427
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
SB  - IM
MH  - Aging/pathology
MH  - Alzheimer Disease/*pathology/*therapy
MH  - Animals
MH  - *Autophagy
MH  - Homeostasis
MH  - Humans
MH  - Neurons/pathology
MH  - Signal Transduction
EDAT- 2013/04/30 06:00
MHDA- 2014/06/19 06:00
CRDT- 2013/04/30 06:00
PHST- 2013/02/25 00:00 [received]
PHST- 2013/04/09 00:00 [accepted]
PHST- 2013/04/30 06:00 [entrez]
PHST- 2013/04/30 06:00 [pubmed]
PHST- 2014/06/19 06:00 [medline]
AID - 10.1007/s12035-013-8457-z [doi]
PST - ppublish
SO  - Mol Neurobiol. 2013 Dec;48(3):702-14. doi: 10.1007/s12035-013-8457-z. Epub 2013 
      Apr 27.