PMID- 23627709
OWN - NLM
STAT- MEDLINE
DCOM- 20140107
LR  - 20220408
IS  - 1875-5828 (Electronic)
IS  - 1567-2050 (Print)
IS  - 1567-2050 (Linking)
VI  - 10
IP  - 5
DP  - 2013 Jun
TI  - Treadmill exercise prevents learning and memory impairment in Alzheimer's 
      disease-like pathology.
PG  - 507-15
AB  - Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by 
      progressive memory loss. In contrast, accumulating evidence suggests a 
      neuroprotective role of regular exercise in aging associated memory impairment. 
      In this study, we investigated the ability of regular exercise to prevent 
      impairments of short-term memory (STM) and early long-term potentiation (E-LTP) 
      in area CA1 of the hippocampus in a rat model of AD (i.c.v. infusion of 250 
      pmol/day Abeta1-42 peptides). We utilized behavioral assessment, in vivo 
      electrophysiological recording, and immunoblotting in 4 groups of adult Wistar 
      rats: control, treadmill exercise (Ex), beta-amyloid-infused (Abeta), and 
      amyloid-infused/treadmill exercised (Ex/Abeta). Our findings indicated that Abeta rats 
      made significantly more errors in the radial arm water maze (RAWM) compared to 
      all other groups and exhibited suppressed E-LTP in area CA1, which correlated 
      with deleterious alterations in the levels of memory and E-LTP-related signaling 
      molecules including calcineurin (PP2B), brain derivedneurotrophic factor (BDNF) 
      and phosphorylated CaMKII (p-CaMKII). Compared to controls, Ex and Ex/Abeta rats 
      showed a similar behavioral performance and a normal E-LTP with no detrimental 
      changes in the levels of PP2B, BDNF, and p- CaMKII. We conclude that treadmill 
      exercise maybe able to prevent cognitive impairment associated with AD pathology.
FAU - Dao, An T
AU  - Dao AT
AD  - Department of PPS, College of Pharmacy, University of Houston, Houston, TX 
      77204-5037, USA.
FAU - Zagaar, Munder A
AU  - Zagaar MA
AD  - Texas Southern University Department of Pharmacy Practice and Clinical Health 
      Sciences Houston, TX 77004
FAU - Levine, Amber T
AU  - Levine AT
FAU - Salim, Samina
AU  - Salim S
FAU - Eriksen, Jason L
AU  - Eriksen JL
FAU - Alkadhi, Karim A
AU  - Alkadhi KA
LA  - eng
GR  - R15 AG039008/AG/NIA NIH HHS/United States
GR  - R15 MH093918/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Alzheimer Res
JT  - Current Alzheimer research
JID - 101208441
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 3.1.3.16 (Calcineurin)
SB  - IM
MH  - Alzheimer Disease/chemically induced/*complications/pathology/*rehabilitation
MH  - Amyloid beta-Peptides/toxicity
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - CA1 Region, Hippocampal/pathology
MH  - Calcineurin/metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism
MH  - Disease Models, Animal
MH  - Drug Delivery Systems
MH  - Electric Stimulation
MH  - Exercise Test
MH  - Learning Disabilities/*prevention & control
MH  - Long-Term Potentiation/drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory Disorders/*prevention & control
MH  - Memory, Short-Term/drug effects
MH  - Peptide Fragments/toxicity
MH  - Physical Conditioning, Animal/*methods
MH  - Rats
MH  - Rats, Wistar
MH  - Up-Regulation/drug effects
PMC - PMC4004077
MID - NIHMS538624
COIS- The authors disclose no conflict of biomedical or financial interest.
EDAT- 2013/05/01 06:00
MHDA- 2014/01/08 06:00
PMCR- 2014/06/01
CRDT- 2013/05/01 06:00
PHST- 2012/08/21 00:00 [received]
PHST- 2013/01/29 00:00 [revised]
PHST- 2013/01/30 00:00 [accepted]
PHST- 2013/05/01 06:00 [entrez]
PHST- 2013/05/01 06:00 [pubmed]
PHST- 2014/01/08 06:00 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - CAR-EPUB-20130430-5 [pii]
AID - 10.2174/1567205011310050006 [doi]
PST - ppublish
SO  - Curr Alzheimer Res. 2013 Jun;10(5):507-15. doi: 10.2174/1567205011310050006.