PMID- 23631499
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20130516
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 16
IP  - 5
DP  - 2013 May
TI  - Possible therapeutic uses of Salvia triloba and Piper nigrum in Alzheimer's 
      disease-induced rats.
PG  - 437-46
LID - 10.1089/jmf.2012.0165 [doi]
AB  - This study aimed to investigate the role of Salvia triloba L. and Piper nigrum 
      extracts in ameliorating neuroinflammatory insults characteristic of Alzheimer's 
      disease (AD) in an experimentally induced rat model. Adult male Sprague-Dawley 
      rats were classified into Group 1 (n=10): normal healthy animals serving as the 
      negative control group; Group 2 (n=60): the AD-induced group. After AD induction, 
      animals in the AD-induced group were divided randomly and equally into 6 
      subgroups. The first subgroup served as AD control; the second one, which served 
      as positive control, was treated orally with the conventional therapy for AD 
      (rivastigmine) at a dose of 0.3 mg/kg body weight (b.w.) daily for 3 months. The 
      third and fourth subgroups were, respectively, treated orally with the S. triloba 
      extract at a dose of 750 and 375 mg/kg b.w. daily for 3 months. The fifth and 
      sixth subgroups were, respectively, treated orally with the P. nigrum extract at 
      a dose of 187.5 and 93.75 mg/kg b.w. daily for 3 months. Levels of brain 
      acetylcholine (Ach), serum and brain acetylcholinesterase (AchE) activity, 
      C-reactive protein (CRP), total nuclear factor kappa-B (NF-kappaB), and monocyte 
      chemoattractant protein-1 (MCP-1) were estimated. The results showed that 
      administration of AlCl3 resulted in a significant elevation in the levels of AchE 
      activity, CRP, NF-kappaB, and MCP-1 accompanied with a significant depletion in the 
      Ach level. Treatment of AD rats with each of the selected medicinal plant 
      extracts caused marked improvement in the measured biochemical parameters. In 
      conclusion, S. triloba and P. nigrum methanolic extracts have potent 
      anti-inflammatory effects against neuroinflammation characterizing AD.
FAU - Ahmed, Hanaa H
AU  - Ahmed HH
AD  - Hormones Department, National Research Center, Cairo 12622, Egypt. 
      hanaaomr@yahoo.com
FAU - Salem, Ahmed M
AU  - Salem AM
FAU - Sabry, Gilane M
AU  - Sabry GM
FAU - Husein, Ahmed A
AU  - Husein AA
FAU - Kotob, Soheir E
AU  - Kotob SE
LA  - eng
PT  - Journal Article
DEP - 20130430
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Chemokine CCL2)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Alzheimer Disease/*drug therapy/genetics/immunology
MH  - Animals
MH  - C-Reactive Protein/genetics/immunology
MH  - Chemokine CCL2/genetics/immunology
MH  - Humans
MH  - Male
MH  - NF-kappa B/genetics/immunology
MH  - Piper nigrum/*chemistry
MH  - Plant Extracts/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Salvia/*chemistry
EDAT- 2013/05/02 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/05/02 06:00
PHST- 2013/05/02 06:00 [entrez]
PHST- 2013/05/02 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.1089/jmf.2012.0165 [doi]
PST - ppublish
SO  - J Med Food. 2013 May;16(5):437-46. doi: 10.1089/jmf.2012.0165. Epub 2013 Apr 30.