PMID- 23631807 OWN - NLM STAT- MEDLINE DCOM- 20140211 LR - 20220331 IS - 1460-2202 (Electronic) IS - 0271-3683 (Linking) VI - 38 IP - 8 DP - 2013 Aug TI - Anterior segment changes produced in response to long-term overnight orthokeratology. PG - 862-70 LID - 10.3109/02713683.2013.790977 [doi] AB - PURPOSE: To evaluate the effect of overnight orthokeratology (OK) on anterior chamber depth (ACD), posterior radius of corneal curvature (PRCC) and axial length (AL) over one year. METHODS: In this prospective longitudinal study, measurements were made in 34 right eyes of 34 subjects at baseline, 15 days, 1 and 12 months after starting OK treatment. ACD and PRCC measurements were obtained using a Pentacam system and AL was measured using an IOL-Master. ACD and PRCC were measured along the horizontal and vertical meridians at 1 mm intervals. These measurements were expressed as the distance from the center in the nasal (N), temporal (T), superior (S) and inferior (I) directions. RESULTS: A significant reduction in ACD was observed in both meridians during treatment. PRCC flattened significantly in the (T) direction after 15 d (1 mm, p < 0.05), at the corneal center after 15 d (p < 0.01), in the (T) direction after 1 month (1 mm, p < 0.05), in the (S) direction after 12 months (1 mm p < 0.05), in the (N) direction after 12 months (1 mm p < 0.05), in the (N) and (T) directions after 12 months (3 mm, p < 0.05) and in the (T) direction after 12 months (4 mm p < 0.05), at the corneal center after 12 months (p < 0.01). AL was significantly reduced during treatment (p < 0.05). CONCLUSIONS: A long period of OK reduces ACD and AL and changes PRCC. FAU - Gonzalez-Mesa, Ana AU - Gonzalez-Mesa A AD - Department of Optics II, University School of Optics, Madrid, Spain. ana.gmesa@gmail.com FAU - Villa-Collar, Cesar AU - Villa-Collar C FAU - Lorente-Velazquez, Amalia AU - Lorente-Velazquez A FAU - Nieto-Bona, Amelia AU - Nieto-Bona A LA - eng PT - Clinical Trial PT - Journal Article DEP - 20130430 PL - England TA - Curr Eye Res JT - Current eye research JID - 8104312 SB - IM MH - Adult MH - *Anterior Chamber MH - Axial Length, Eye MH - *Contact Lenses MH - Female MH - Humans MH - Longitudinal Studies MH - Male MH - Myopia/*therapy MH - Orthokeratologic Procedures/*methods MH - Photography/methods/standards MH - Prospective Studies MH - Reproducibility of Results MH - Statistics, Nonparametric MH - Treatment Outcome MH - Visual Acuity MH - Young Adult EDAT- 2013/05/02 06:00 MHDA- 2014/02/12 06:00 CRDT- 2013/05/02 06:00 PHST- 2013/05/02 06:00 [entrez] PHST- 2013/05/02 06:00 [pubmed] PHST- 2014/02/12 06:00 [medline] AID - 10.3109/02713683.2013.790977 [doi] PST - ppublish SO - Curr Eye Res. 2013 Aug;38(8):862-70. doi: 10.3109/02713683.2013.790977. Epub 2013 Apr 30.