PMID- 23631927
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20220311
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 64
IP  - 1
DP  - 2013 Jun
TI  - Spatial memory deficits in maternal iron deficiency paradigms are associated with 
      altered glucocorticoid levels.
PG  - 26-36
LID - S0018-506X(13)00093-7 [pii]
LID - 10.1016/j.yhbeh.2013.04.005 [doi]
AB  - "The goal of this study was to examine the effect of maternal iron deficiency on 
      the developing hippocampus in order to define a developmental window for this 
      effect, and to see whether iron deficiency causes changes in glucocorticoid 
      levels. The study was carried out using pre-natal, post-natal, and pre+post-natal 
      iron deficiency paradigm. Iron deficient pregnant dams and their pups displayed 
      elevated corticosterone which, in turn, differentially affected glucocorticoid 
      receptor (GR) expression in the CA1 and the dentate gyrus. Brain Derived 
      Neurotrophic Factor (BDNF) was reduced in the hippocampi of pups following 
      elevated corticosterone levels. Reduced neurogenesis at P7 was seen in pups born 
      to iron deficient mothers, and these pups had reduced numbers of hippocampal 
      pyramidal and granule cells as adults. Hippocampal subdivision volumes also were 
      altered. The structural and molecular defects in the pups were correlated with 
      radial arm maze performance; reference memory function was especially affected. 
      Pups from dams that were iron deficient throughout pregnancy and lactation 
      displayed the complete spectrum of defects, while pups from dams that were iron 
      deficient only during pregnancy or during lactation displayed subsets of defects. 
      These findings show that maternal iron deficiency is associated with altered 
      levels of corticosterone and GR expression, and with spatial memory deficits in 
      their pups."
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Ranade, Sayali C
AU  - Ranade SC
AD  - National Brain Research Centre, NH-8, Manesar, Haryana-122050, India. 
      sayali@nbrc.ac.in
FAU - Nawaz, Sarfaraz
AU  - Nawaz S
FAU - Chakrabarti, Arnab
AU  - Chakrabarti A
FAU - Gressens, Pierre
AU  - Gressens P
FAU - Mani, Shyamala
AU  - Mani S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130428
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Antimetabolites)
RN  - 0 (Glucocorticoids)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antimetabolites
MH  - Bromodeoxyuridine
MH  - Cell Count
MH  - Dentate Gyrus/metabolism
MH  - Female
MH  - Glucocorticoids/*metabolism
MH  - Hippocampus/metabolism
MH  - Immunohistochemistry
MH  - *Iron Deficiencies
MH  - Maze Learning/physiology
MH  - Memory Disorders/*psychology
MH  - Memory, Short-Term/physiology
MH  - Mice
MH  - Neurogenesis/physiology
MH  - Neuroglia/physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/psychology
MH  - Psychomotor Performance/physiology
MH  - Space Perception/*physiology
EDAT- 2013/05/02 06:00
MHDA- 2014/02/05 06:00
CRDT- 2013/05/02 06:00
PHST- 2012/08/11 00:00 [received]
PHST- 2013/04/10 00:00 [revised]
PHST- 2013/04/11 00:00 [accepted]
PHST- 2013/05/02 06:00 [entrez]
PHST- 2013/05/02 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - S0018-506X(13)00093-7 [pii]
AID - 10.1016/j.yhbeh.2013.04.005 [doi]
PST - ppublish
SO  - Horm Behav. 2013 Jun;64(1):26-36. doi: 10.1016/j.yhbeh.2013.04.005. Epub 2013 Apr 
      28.