PMID- 23632006
OWN - NLM
STAT- MEDLINE
DCOM- 20140715
LR  - 20131129
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 32
IP  - 12
DP  - 2013 Dec
TI  - Effect of subacute exposure to silver nanoparticle on some hematological and 
      plasma biochemical indices in silver carp (Hypophthalmichthys molitrix).
PG  - 1270-7
LID - 10.1177/0960327113485258 [doi]
AB  - The use of silver nanoparticles (Ag-NPs) is rapidly increasing, but there are 
      limited data on their effects on the aquatic environment. The present study aimed 
      to determine the acute toxicity and evaluate the effect of subacute 
      concentrations of Ag-NPs (Nanocid(R): average particle size of 61 nm) on 
      hematological and plasma biochemical indices of silver carp, Hypophthalmichthys 
      molitrix, after 3, 7 and 14 days. The 24-, 48-, 72- and 96-h median lethal 
      concentration (LC50) values of Nanocid for silver carp were estimated at 0.810, 
      0.648, 0.383 and 0.202 mg/L, respectively; 20% and 10% of the 96-h LC50 values 
      (0.04 and 0.02 mg/L) were selected for subacute study. Red blood cell (RBC) 
      count, hemoglobin (Hb) count and hematocrit (Hct) level were significantly 
      reduced at both concentrations tested (p < 0.05). White blood cell (WBC), mean 
      corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), 
      cortisol and glucose levels in Nanocid-treated groups were significantly higher 
      than the controlled group at experimental periods (p < 0.05). In conclusion, 
      Ag-NPs intoxication resulted in erythrocyte reduction, hematological 
      disturbances, leucocytosis and stress response in silver carp and offered a 
      simple tool to evaluate toxicity-derived alterations.
FAU - Shaluei, F
AU  - Shaluei F
AD  - 1Young Researchers Club, Gorgan Branch, Islamic Azad University, Gorgan, Islamic 
      Republic of Iran.
FAU - Hedayati, A
AU  - Hedayati A
FAU - Jahanbakhshi, A
AU  - Jahanbakhshi A
FAU - Kolangi, H
AU  - Kolangi H
FAU - Fotovat, M
AU  - Fotovat M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130430
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Hemoglobins)
RN  - 0 (Water Pollutants, Chemical)
RN  - 3M4G523W1G (Silver)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*toxicity
MH  - Blood Glucose/analysis
MH  - Carps/*metabolism
MH  - Erythrocyte Count
MH  - Erythrocyte Indices
MH  - Hematocrit
MH  - Hemoglobins/analysis
MH  - Hydrocortisone/blood
MH  - Lethal Dose 50
MH  - Leukocyte Count
MH  - Metal Nanoparticles/*toxicity
MH  - Silver/*toxicity
MH  - Toxicity Tests, Acute
MH  - Toxicity Tests, Subacute
MH  - Water Pollutants, Chemical/*toxicity
OTO - NOTNLM
OT  - Ag-NPs
OT  - Nanocid(R)
OT  - fish
OT  - nanotoxicology
OT  - toxicity test
EDAT- 2013/05/02 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/05/02 06:00
PHST- 2013/05/02 06:00 [entrez]
PHST- 2013/05/02 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 0960327113485258 [pii]
AID - 10.1177/0960327113485258 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2013 Dec;32(12):1270-7. doi: 10.1177/0960327113485258. Epub 2013 
      Apr 30.