PMID- 23632237
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20181202
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 110
IP  - 10
DP  - 2013 Nov
TI  - Lycopene supplementation modulates plasma concentrations and epididymal adipose 
      tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats.
PG  - 1803-9
LID - 10.1017/S0007114513001256 [doi]
AB  - Obesity is characterised by chronic low-grade inflammation, and lycopene has been 
      reported to display anti-inflammatory effects. However, it is not clear whether 
      lycopene supplementation modulates adipokine levels in vivo in obesity. To 
      determine whether lycopene supplementation can regulate adipokine expression in 
      obesity, male Wistar rats were randomly assigned to receive a control diet (C, n 
      6) ora hyperenergetic diet (DIO, n 12) for 6 weeks. After this period, the DIO 
      animals were randomised into two groups: DIO (n 6) and DIO supplemented with 
      lycopene (DIO + L, n 6). The animals received maize oil (C and DIO) or lycopene 
      (DIO + L, 10 mg/kg body weight(BW) per d) by oral administration for a 6-week 
      period. The animals were then killed by decapitation, and blood samples and 
      epididymal adipose tissue were collected for hormonal determination and gene 
      expression evaluation (IL-6, monocyte chemoattractant protein-1(MCP-1), TNF-alpha, 
      leptin and resistin). There was no detectable lycopene in the plasma of the C and 
      DIO groups. However, the mean lycopene plasma concentration was 24 nmol in the 
      DIO + L group. Although lycopene supplementation did not affect BW or adiposity, 
      it significantly decreased leptin, resistin and IL-6 gene expression in 
      epididymal adipose tissue and plasma concentrations. Also, it significantly 
      reduced the gene expression of MCP-1 in epididymal adipose tissue. Lycopene 
      affects adipokines by reducing leptin, resistin and plasma IL-6 levels. These 
      data suggest that lycopene may be an effective strategy in reducing inflammation 
      in obesity.
FAU - Luvizotto, Renata de Azevedo Melo
AU  - Luvizotto Rde A
AD  - Internal Medicine Laboratory, Department of Internal Medicine, Botucatu Medical 
      School, Sao Paulo State University (UNESP), Distrito Rubiao Jr. s/n, 18618-970 
      Botucatu, SP, Brazil.
FAU - Nascimento, Andre F
AU  - Nascimento AF
FAU - Imaizumi, Erika
AU  - Imaizumi E
FAU - Pierine, Damiana T
AU  - Pierine DT
FAU - Conde, Sandro J
AU  - Conde SJ
FAU - Correa, Camila R
AU  - Correa CR
FAU - Yeum, Kyung-Jin
AU  - Yeum KJ
FAU - Ferreira, Ana Lucia A
AU  - Ferreira AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130501
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - 0 (Resistin)
RN  - 36-88-4 (Carotenoids)
RN  - SB0N2N0WV6 (Lycopene)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Carotenoids/blood/pharmacology/*therapeutic use
MH  - Dietary Supplements
MH  - Energy Intake
MH  - Epididymis
MH  - Inflammation/*drug therapy/etiology/genetics/metabolism
MH  - Interleukin-6/genetics/*metabolism
MH  - Leptin/genetics/*metabolism
MH  - Lycopene
MH  - Male
MH  - Obesity/complications/*drug therapy/genetics/metabolism
MH  - Phytotherapy
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - RNA, Messenger/metabolism
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Resistin/genetics/*metabolism
EDAT- 2013/05/02 06:00
MHDA- 2013/12/24 06:00
CRDT- 2013/05/02 06:00
PHST- 2013/05/02 06:00 [entrez]
PHST- 2013/05/02 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - S0007114513001256 [pii]
AID - 10.1017/S0007114513001256 [doi]
PST - ppublish
SO  - Br J Nutr. 2013 Nov;110(10):1803-9. doi: 10.1017/S0007114513001256. Epub 2013 May 
      1.