PMID- 23633236
OWN - NLM
STAT- MEDLINE
DCOM- 20140416
LR  - 20140304
IS  - 1934-6638 (Electronic)
IS  - 1934-662X (Linking)
VI  - 121
IP  - 11
DP  - 2013 Nov
TI  - Improving the accuracy of pancreatobiliary tract cytology with fluorescence in 
      situ hybridization: a molecular test with proven clinical success.
PG  - 610-9
LID - 10.1002/cncy.21303 [doi]
AB  - The detection of aneuploidy by fluorescence in situ hybridization (FISH) has 
      revolutionized how laboratories diagnose cholangiocarcinoma and pancreatic 
      adenocarcinoma using cytology specimens. Numerous clinical studies have 
      demonstrated that FISH increases the diagnostic sensitivity of routine cytology 
      for detecting pancreatobiliary tract malignancy with minimal decreases in 
      clinical specificity. FISH also provides useful information in difficult clinical 
      scenarios, including the assessment of patients with biliary strictures who have 
      equivocal cytology results and the assessment of patients with primary sclerosing 
      cholangitis who have clinical features suggestive of malignancy. The improved 
      ability to detect pancreatobiliary tract cancers offers the possibility of 
      earlier detection when patients are amenable to surgical intervention and can 
      decrease health care costs by reducing the amount of clinical evaluation required 
      to arrive at a cancer diagnosis. Cytopathology personnel should maintain 
      familiarity with molecular cytology testing methodologies, because morphologic 
      and aneuploidy assessment of tumors will continue to be an integral part of 
      large-scale genome analyses of individual tumors.
CI  - (c) 2013 American Cancer Society.
FAU - Kipp, Benjamin R
AU  - Kipp BR
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, 
      Rochester, Minnesota.
FAU - Barr Fritcher, Emily G
AU  - Barr Fritcher EG
FAU - Pettengill, Jennifer E
AU  - Pettengill JE
FAU - Halling, Kevin C
AU  - Halling KC
FAU - Clayton, Amy C
AU  - Clayton AC
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130430
PL  - United States
TA  - Cancer Cytopathol
JT  - Cancer cytopathology
JID - 101499453
SB  - IM
MH  - Adenocarcinoma/genetics/*pathology
MH  - Aneuploidy
MH  - Bile Duct Neoplasms/genetics/*pathology
MH  - Cholangiocarcinoma/genetics/*pathology
MH  - Cholangitis, Sclerosing/genetics/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Pancreatic Neoplasms/genetics/*pathology
OTO - NOTNLM
OT  - UroVysion
OT  - bile duct
OT  - cholangiocarcinoma
OT  - fluorescence in situ hybridization
OT  - pancreas
OT  - primary sclerosing cholangitis
EDAT- 2013/05/02 06:00
MHDA- 2014/04/17 06:00
CRDT- 2013/05/02 06:00
PHST- 2013/02/15 00:00 [received]
PHST- 2013/03/21 00:00 [revised]
PHST- 2013/04/01 00:00 [accepted]
PHST- 2013/05/02 06:00 [entrez]
PHST- 2013/05/02 06:00 [pubmed]
PHST- 2014/04/17 06:00 [medline]
AID - 10.1002/cncy.21303 [doi]
PST - ppublish
SO  - Cancer Cytopathol. 2013 Nov;121(11):610-9. doi: 10.1002/cncy.21303. Epub 2013 Apr 
      30.