PMID- 23633758
OWN - NLM
STAT- MEDLINE
DCOM- 20140109
LR  - 20211021
IS  - 1550-9109 (Electronic)
IS  - 0161-8105 (Print)
IS  - 0161-8105 (Linking)
VI  - 36
IP  - 5
DP  - 2013 May 1
TI  - Regular exercise prevents sleep deprivation associated impairment of long-term 
      memory and synaptic plasticity in the CA1 area of the hippocampus.
PG  - 751-61
LID - 10.5665/sleep.2642 [doi]
AB  - STUDY OBJECTIVES: The present study aimed to investigate the effects of treadmill 
      exercise on sleep deprivation (S-D)-induced impairment of hippocampal dependent 
      long-term memory, late phase long-term potentiation (L-LTP) and its signaling 
      cascade in the cornu ammonis 1 (CA1) area. EXPERIMENTAL DESIGN: Animals were 
      conditioned to run on treadmills for 4 weeks then deprived of sleep for 24 h 
      using the columns-in-water method. We tested the effect of exercise and/or S-D on 
      behavioral performance using a post-learning paradigm in the radial arm water 
      maze (RAWM) and in vivo extracellular recording in the CA1 area. The levels of 
      L-LTP-related molecules in the CA1 area were then assessed both before and after 
      L-LTP induction. MEASUREMENTS AND RESULTS: After 24 h of S-D, spatial long-term 
      memory impairment in the RAWM and L-LTP suppression was prevented by 4 weeks of 
      regular exercise. Regular exercise also restored the S-D-associated decreases in 
      the basal levels of key signaling molecules such as: calcium/calmodulin kinase IV 
      (CaMKIV), mitogen-activated protein kinase (MAPK/ERK), phosphorylated cAMP 
      response element-binding protein (P-CREB) and brain derived neurotrophic factor 
      (BDNF), in the CA1 area. After L-LTP induction, regular exercise also prevented 
      the S-D-induced down regulation of BDNF and P-CREB protein levels. CONCLUSIONS: 
      The results suggest that our exercise protocol may prevent 24-h S-D-induced 
      impairments in long-term memory and LTP by preventing deleterious changes in the 
      basal and post-stimulation levels of P-CREB and BDNF associated with S-D.
FAU - Zagaar, Munder
AU  - Zagaar M
AD  - Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 
      TX.
FAU - Dao, An
AU  - Dao A
FAU - Levine, Amber
AU  - Levine A
FAU - Alhaider, Ibrahim
AU  - Alhaider I
FAU - Alkadhi, Karim
AU  - Alkadhi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130501
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - CA1 Region, Hippocampal/*physiology
MH  - Disease Models, Animal
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory Disorders/etiology/*prevention & control
MH  - Memory, Long-Term/*physiology
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Signal Transduction/physiology
MH  - Sleep Deprivation/*complications
PMC - PMC3624830
OTO - NOTNLM
OT  - BDNF
OT  - CREB
OT  - ERK1/2
OT  - LTP
OT  - RAWM
OT  - Sleep deprivation
OT  - forced exercise
EDAT- 2013/05/02 06:00
MHDA- 2014/01/10 06:00
PMCR- 2013/11/01
CRDT- 2013/05/02 06:00
PHST- 2013/05/02 06:00 [entrez]
PHST- 2013/05/02 06:00 [pubmed]
PHST- 2014/01/10 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - 10.5665/sleep.2642 [doi]
PST - epublish
SO  - Sleep. 2013 May 1;36(5):751-61. doi: 10.5665/sleep.2642.