PMID- 23634262
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130502
LR  - 20211021
IS  - 2005-3711 (Print)
IS  - 1598-7876 (Electronic)
IS  - 1225-8245 (Linking)
VI  - 53
IP  - 3
DP  - 2013 Mar
TI  - Isoflurane Induces Transient Anterograde Amnesia through Suppression of 
      Brain-Derived Neurotrophic Factor in Hippocampus.
PG  - 139-44
LID - 10.3340/jkns.2013.53.3.139 [doi]
AB  - OBJECTIVE: Transient anterograde amnesia is occasionally observed in a number of 
      conditions, including migraine, focal ischemia, venous flow abnormalities, and 
      after general anesthesia. The inhalation anesthetic, isoflurane, is known to 
      induce transient anterograde amnesia. We examined the involvement of 
      brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B 
      (TrkB) in the underlying mechanisms of the isoflurane-induced transient 
      anterograde amnesia. METHODS: Adult male Sprague-Dawley rats were divided into 
      three groups : the control group, the 10 minutes after recovery from isoflurane 
      anesthesia group, and the 2 hours after recovery from isoflurane anesthesia group 
      (n=8 in each group). The rats in the isoflurane-exposed groups were anesthetized 
      with 1.2% isoflurane in 75% nitrous oxide and 25% oxygen for 2 hours in a 
      Plexiglas anesthetizing chamber. Short-term memory was determined using the 
      step-down avoidance task. BDNF and TrkB expressions in the hippocampus were 
      evaluated by immunofluorescence staining and western blot analysis. RESULTS: 
      Latency in the step-down avoidance task was decreased 10 minutes after recovery 
      from isoflurane anesthesia, whereas it recovered to the control level 2 hours 
      after isoflurane anesthesia. The expressions of BDNF and TrkB in the hippocampus 
      were decreased immediately after isoflurane anesthesia but were increased 2 hours 
      after isoflurane anesthesia. CONCLUSION: In this study, isoflurane anesthesia 
      induced transient anterograde amnesia, and the expressions of BDNF and TrkB in 
      the hippocampus might be involved in the underlying mechanisms of this transient 
      anterograde amnesia.
FAU - Cho, Han-Jin
AU  - Cho HJ
AD  - Department of Emergency Medicine, Korea University College of Medicine, Ansan 
      Hospital, Ansan, Korea.
FAU - Sung, Yun-Hee
AU  - Sung YH
FAU - Lee, Seung-Hwan
AU  - Lee SH
FAU - Chung, Jun-Young
AU  - Chung JY
FAU - Kang, Jong-Man
AU  - Kang JM
FAU - Yi, Jae-Woo
AU  - Yi JW
LA  - eng
PT  - Journal Article
DEP - 20130331
PL  - Korea (South)
TA  - J Korean Neurosurg Soc
JT  - Journal of Korean Neurosurgical Society
JID - 101467054
PMC - PMC3638265
OTO - NOTNLM
OT  - Anterograde amnesia
OT  - Brain-derived neurotrophic factor
OT  - Hippocampus
OT  - Isoflurane
OT  - Tyrosine kinase B receptor
EDAT- 2013/05/02 06:00
MHDA- 2013/05/02 06:01
PMCR- 2013/03/01
CRDT- 2013/05/02 06:00
PHST- 2012/04/12 00:00 [received]
PHST- 2012/08/18 00:00 [revised]
PHST- 2013/02/25 00:00 [accepted]
PHST- 2013/05/02 06:00 [entrez]
PHST- 2013/05/02 06:00 [pubmed]
PHST- 2013/05/02 06:01 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - 10.3340/jkns.2013.53.3.139 [doi]
PST - ppublish
SO  - J Korean Neurosurg Soc. 2013 Mar;53(3):139-44. doi: 10.3340/jkns.2013.53.3.139. 
      Epub 2013 Mar 31.