PMID- 23635079
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20210915
IS  - 1532-2513 (Electronic)
IS  - 0892-3973 (Linking)
VI  - 35
IP  - 3
DP  - 2013 Jun
TI  - Dihydroartemisinin suppresses ovalbumin-induced airway inflammation in a mouse 
      allergic asthma model.
PG  - 382-9
LID - 10.3109/08923973.2013.785559 [doi]
AB  - Asthma is a complex disease characterized by reversible airway obstruction, 
      airway hyper-responsiveness (AHR) and chronic inflammation of the airways. 
      Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin isolated 
      from the traditional Chinese herb Artemisia annua, has been shown to possess 
      antimalarial and antitumor activities, but whether it can be used in asthma 
      treatment has not been investigated. In this study, we attempted to determine 
      whether DHA regulates inflammatory mediators in the ovalbumin (OVA)-induced mouse 
      asthma model. BALB/c mice were sensitized and challenged by OVA to induce chronic 
      airway inflammation. The intragastrical administration of DHA at 30 mg/kg 
      significantly decreased the number of infiltrating inflammatory cells, T-helper 
      type 2 (Th2) cytokines, OVA-specific immunoglobulin E (IgE) and AHR. Treatment 
      with DHA also attenuated OVA-induced mRNA expression of Muc5ac and chitinase 
      3-like protein 4 (Ym2) in lung tissues. In addition, lung histopathological 
      studies revealed that DHA inhibited inflammatory cell infiltration and mucus 
      hypersecretion. Then signal transduction studies showed that DHA significantly 
      inhibited extracellular signal-regulated protein kinase (ERK), p38 
      mitogen-activated protein kinase phosphorylation. DHA also inhibited nuclear 
      factor-kappaB (NF-kappaB) activation via the inhibition of phosphorylation of IkappaBalpha. These 
      findings provide new insight into the immunopharmacological role of DHA in terms 
      of its effects in a mouse model of asthma.
FAU - Wei, Miaomiao
AU  - Wei M
AD  - Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College 
      of Animal Science and Veterinary Medicine, Jilin University, Changchun, China.
FAU - Xie, Xianxing
AU  - Xie X
FAU - Chu, Xiao
AU  - Chu X
FAU - Yang, Xiaofeng
AU  - Yang X
FAU - Guan, Mingfeng
AU  - Guan M
FAU - Wang, Dacheng
AU  - Wang D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130501
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Artemisinins)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 6A9O50735X (artenimol)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Asthmatic Agents/administration & dosage/*therapeutic use
MH  - Artemisinins/administration & dosage/*therapeutic use
MH  - Asthma/immunology/pathology/*prevention & control
MH  - Bronchoalveolar Lavage Fluid/chemistry/cytology/immunology
MH  - Cytokines/blood/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Goblet Cells/drug effects/immunology/pathology
MH  - Immunoglobulin E/blood/immunology
MH  - Inflammation/immunology/pathology
MH  - Inflammation Mediators/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mucus/metabolism
MH  - Ovalbumin/immunology
MH  - Respiratory Hypersensitivity/immunology/prevention & control
MH  - Respiratory System/*drug effects/immunology/pathology
MH  - Th2 Cells/drug effects/immunology
EDAT- 2013/05/03 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/05/03 06:00
PHST- 2013/05/03 06:00 [entrez]
PHST- 2013/05/03 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - 10.3109/08923973.2013.785559 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2013 Jun;35(3):382-9. doi: 
      10.3109/08923973.2013.785559. Epub 2013 May 1.