PMID- 23636998
OWN - NLM
STAT- MEDLINE
DCOM- 20140331
LR  - 20211103
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 23
IP  - 9
DP  - 2013 Sep
TI  - Duodenal-jejunal bypass improves glucose metabolism and adipokine expression 
      independently of weight loss in a diabetic rat model.
PG  - 1436-44
LID - 10.1007/s11695-013-0976-1 [doi]
AB  - BACKGROUND: There is accumulating evidence that adipokines lead to a 
      proinflammatory state, which plays crucial roles in insulin resistance and 
      development of type 2 diabetes mellitus (T2DM). Previous studies demonstrated 
      that weight loss after bariatric surgery is accompanied by a suppression of the 
      proinflammatory state. However, the effect of bariatric surgery on adipokine 
      expression beyond weight loss is still elusive. The aim of this study was to 
      investigate the effect of duodenal-jejunal bypass (DJB) on glucose homeostasis 
      and adipokine expression independently of weight loss. METHODS: A T2DM rat model 
      was developed by a high-fat diet and low dose of streptozotocin. Twenty-one 
      diabetic rats and 10 age-matched SD rats were randomly assigned to the DJB group, 
      sham-DJB (S-DJB) group, and control group. For 12 weeks after surgery, their body 
      weight, food intake, glucose homeostasis, lipid parameters, serum adipokine 
      levels, and adipokine gene expression in the mesocolon adipose tissue were 
      measured. RESULTS: Compared to the S-DJB group, DJB induced significant and 
      sustained glycemic control with improved insulin sensitivity and glucose 
      tolerance independently of weight loss. DJB improved the lipid metabolism by 
      decreasing fasting free fatty acids and triglycerides. Serum leptin and IL-6 
      significantly decreased 12 weeks after DJB, whereas adiponectin increased and 
      TNF-alpha remained unchanged. The mRNA expression levels of leptin, TNF-alpha, and IL-6 
      decreased, whereas adiponectin increased in the mesocolon adipose tissue. 
      CONCLUSION: DJB reduced the proinflammatory adipokines and increased the 
      anti-inflammatory adipokines independently of weight loss, which may contribute 
      to the improvement of insulin sensitivity.
FAU - Hu, Chunxiao
AU  - Hu C
AD  - Department of General Surgery, Qilu Hospital of Shandong University, 107#, Wenhua 
      Xi Road, Jinan 250012, Shandong, PR China.
FAU - Zhang, Guangyong
AU  - Zhang G
FAU - Sun, Dong
AU  - Sun D
FAU - Han, Haifeng
AU  - Han H
FAU - Hu, Sanyuan
AU  - Hu S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
RN  - 0 (Adiponectin)
RN  - 0 (Blood Glucose)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adiponectin/metabolism
MH  - Adipose Tissue/immunology/*metabolism
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight
MH  - Diabetes Mellitus, Experimental/metabolism
MH  - Diabetes Mellitus, Type 2/immunology/*metabolism/*surgery
MH  - Duodenum/metabolism/*surgery
MH  - Eating
MH  - *Gastric Bypass
MH  - Gene Expression Regulation
MH  - Glucose/*metabolism
MH  - Homeostasis
MH  - Insulin Resistance
MH  - Interleukin-6/metabolism
MH  - Jejunum/metabolism/*surgery
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Weight Loss/immunology
EDAT- 2013/05/03 06:00
MHDA- 2014/04/01 06:00
CRDT- 2013/05/03 06:00
PHST- 2013/05/03 06:00 [entrez]
PHST- 2013/05/03 06:00 [pubmed]
PHST- 2014/04/01 06:00 [medline]
AID - 10.1007/s11695-013-0976-1 [doi]
PST - ppublish
SO  - Obes Surg. 2013 Sep;23(9):1436-44. doi: 10.1007/s11695-013-0976-1.