PMID- 23637329
OWN - NLM
STAT- MEDLINE
DCOM- 20130716
LR  - 20211021
IS  - 1477-9129 (Electronic)
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 140
IP  - 11
DP  - 2013 Jun
TI  - Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into 
      glomeruli and for male-male aggression.
PG  - 2398-408
LID - 10.1242/dev.087262 [doi]
AB  - The accessory olfactory system controls social and sexual interactions in mice 
      that are crucial for survival. Vomeronasal sensory neurons (VSNs) form synapses 
      with dendrites of second order neurons in glomeruli of the accessory olfactory 
      bulb (AOB). Axons of VSNs expressing the same vomeronasal receptor coalesce into 
      multiple glomeruli within spatially conserved regions of the AOB. Here we examine 
      the role of the Kirrel family of transmembrane proteins in the coalescence of VSN 
      axons within the AOB. We find that Kirrel2 and Kirrel3 are differentially 
      expressed in subpopulations of VSNs and that their expression is regulated by 
      activity. Although Kirrel3 expression is not required for early axonal guidance 
      events, such as fasciculation of the vomeronasal tract and segregation of apical 
      and basal VSN axons in the AOB, it is necessary for proper coalescence of axons 
      into glomeruli. Ablation of Kirrel3 expression results in disorganization of the 
      glomerular layer of the posterior AOB and formation of fewer, larger glomeruli. 
      Furthermore, Kirrel3(-/-) mice display a loss of male-male aggression in a 
      resident-intruder assay. Taken together, our results indicate that differential 
      expression of Kirrels on vomeronasal axons generates a molecular code that 
      dictates their proper coalescence into glomeruli within the AOB.
FAU - Prince, Janet E A
AU  - Prince JE
AD  - Montreal Neurological Institute, Centre for Neuronal Survival, 3801 University, 
      Montreal, Quebec, H3A 2B4, Canada.
FAU - Brignall, Alexandra C
AU  - Brignall AC
FAU - Cutforth, Tyler
AU  - Cutforth T
FAU - Shen, Kang
AU  - Shen K
FAU - Cloutier, Jean-Francois
AU  - Cloutier JF
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
GR  - Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130501
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Immunoglobulins)
RN  - 0 (Kirrel3 protein, mouse)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neph3 protein, mouse)
SB  - IM
MH  - Aggression
MH  - Animals
MH  - Axons/*physiology
MH  - Behavior, Animal
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Developmental
MH  - Immunoglobulins/metabolism
MH  - In Situ Hybridization
MH  - Male
MH  - Membrane Proteins/genetics/metabolism/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Microscopy, Fluorescence
MH  - Olfactory Pathways/*physiology
MH  - Vomeronasal Organ/*metabolism
PMC - PMC3653560
OTO - NOTNLM
OT  - Axon guidance
OT  - Kirrel
OT  - Mouse
OT  - Olfactory system
EDAT- 2013/05/03 06:00
MHDA- 2013/07/17 06:00
PMCR- 2013/12/01
CRDT- 2013/05/03 06:00
PHST- 2013/05/03 06:00 [entrez]
PHST- 2013/05/03 06:00 [pubmed]
PHST- 2013/07/17 06:00 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - dev.087262 [pii]
AID - 10.1242/dev.087262 [doi]
PST - ppublish
SO  - Development. 2013 Jun;140(11):2398-408. doi: 10.1242/dev.087262. Epub 2013 May 1.