PMID- 23638994
OWN - NLM
STAT- MEDLINE
DCOM- 20140630
LR  - 20211021
IS  - 1557-9077 (Electronic)
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 23
IP  - 11
DP  - 2013 Nov
TI  - Low-normal free thyroxine confers decreased serum bilirubin in type 2 diabetes 
      mellitus.
PG  - 1367-73
LID - 10.1089/thy.2013.0156 [doi]
AB  - BACKGROUND: Bilirubin may confer cardiovascular protection because of its strong 
      antioxidative properties. Both thyroid dysfunction and the diabetic state affect 
      bilirubin metabolism. Here we tested whether low-normal thyroid function affects 
      serum bilirubin among euthyroid subjects with and without type 2 diabetes 
      mellitus (T2DM). METHODS: Serum total bilirubin, thyrotropin and free thyroxine 
      (free T4), transaminases, insulin sensitivity (homeostasis model assessment), and 
      lipids were measured in 74 T2DM and 82 nondiabetic subjects with thyrotropin and 
      free T4 levels within the euthyroid range. RESULTS: Bilirubin was positively 
      related to free T4 in T2DM subjects (r = 0.370, p < 0.001), but not in 
      nondiabetic subjects (r = 0.047, p = 0.68). In age- and sex-adjusted multiple 
      linear regression analysis, free T4 was found to interact positively with the 
      presence of T2DM on serum bilirubin (interaction term: beta = 0.251, p = 0.024). 
      This interaction remained present after additional adjustment for alcohol intake, 
      aspartate aminotransferase and insulin sensitivity (interaction term: beta = 0.222, 
      p = 0.043), or alternatively for cholesterol and triglycerides (interaction term: 
      beta = 0.203, p = 0.057). CONCLUSIONS: Lower free T4 levels within the euthyroid 
      range confer decreased bilirubin in T2DM. Low-normal thyroid function could 
      enhance atherosclerosis susceptibility in T2DM by decreasing serum bilirubin.
FAU - Deetman, Petronella E
AU  - Deetman PE
AD  - Department of Internal Medicine, University of Groningen and University Medical 
      Center Groningen , Groningen, The Netherlands .
FAU - Kwakernaak, Arjan J
AU  - Kwakernaak AJ
FAU - Bakker, Stephan J L
AU  - Bakker SJ
FAU - Dullaart, Robin P F
AU  - Dullaart RP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130904
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Antioxidants)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 9002-71-5 (Thyrotropin)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - Q51BO43MG4 (Thyroxine)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Aged
MH  - Antioxidants/metabolism
MH  - Aspartate Aminotransferases/metabolism
MH  - Atherosclerosis/metabolism
MH  - Bilirubin/*blood
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Homeostasis
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress
MH  - Regression Analysis
MH  - Thyroid Function Tests
MH  - Thyroid Gland/metabolism/*physiology
MH  - Thyrotropin/blood
MH  - Thyroxine/*blood
MH  - Triglycerides/blood
PMC - PMC3822386
EDAT- 2013/05/04 06:00
MHDA- 2014/07/01 06:00
PMCR- 2014/11/01
CRDT- 2013/05/04 06:00
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2014/07/01 06:00 [medline]
PHST- 2014/11/01 00:00 [pmc-release]
AID - 10.1089/thy.2013.0156 [pii]
AID - 10.1089/thy.2013.0156 [doi]
PST - ppublish
SO  - Thyroid. 2013 Nov;23(11):1367-73. doi: 10.1089/thy.2013.0156. Epub 2013 Sep 4.