PMID- 23639116
OWN - NLM
STAT- MEDLINE
DCOM- 20140716
LR  - 20151119
IS  - 1365-3040 (Electronic)
IS  - 0140-7791 (Linking)
VI  - 37
IP  - 1
DP  - 2014 Jan
TI  - GOLLUM [FeFe]-hydrogenase-like proteins are essential for plant development in 
      normoxic conditions and modulate energy metabolism.
PG  - 54-69
LID - 10.1111/pce.12128 [doi]
AB  - [FeFe]-hydrogenase-like genes encode [Fe4 S4]-containing proteins that are 
      ubiquitous in eukaryotic cells. In humans, iron-only hydrogenase-like protein 1 
      (IOP1) represses hypoxia inducible factor-1alpha subunit (HIF1-alpha) at normal 
      atmospheric partial O2 pressure (normoxia, 21 kPa O2). In yeasts, the nar1 mutant 
      cannot grow at 21 kPa O2, but can develop at a lower O2 pressure (2 kPa O2). We 
      show here that plant [FeFe]-hydrogenase-like GOLLUM genes are essential for plant 
      development and cell cycle progression. The mutant phenotypes of these plants are 
      seen in normoxic conditions, but not under conditions of mild hypoxia (5 kPa O2). 
      Transcriptomic and metabolomic experiments showed that the mutation enhances the 
      expression of some hypoxia-induced genes under normal atmospheric O2 conditions 
      and changes the cellular content of metabolites related to energy metabolism. In 
      conclusion, [FeFe]-hydrogenase-like proteins play a central role in eukaryotes 
      including the adaptation of plants to the ambient O2 partial pressure.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Mondy, Samuel
AU  - Mondy S
AD  - CNRS, Institut des Sciences du Vegetal, Av. de la Terrasse, F-91198, Gif sur 
      Yvette, France.
FAU - Lenglet, Aurore
AU  - Lenglet A
FAU - Cosson, Viviane
AU  - Cosson V
FAU - Pelletier, Sandra
AU  - Pelletier S
FAU - Pateyron, Stephanie
AU  - Pateyron S
FAU - Gilard, Francoise
AU  - Gilard F
FAU - Scholte, Marije
AU  - Scholte M
FAU - Brocard, Lysiane
AU  - Brocard L
FAU - Couzigou, Jean-Malo
AU  - Couzigou JM
FAU - Tcherkez, Guillaume
AU  - Tcherkez G
FAU - Pean, Michel
AU  - Pean M
FAU - Ratet, Pascal
AU  - Ratet P
LA  - eng
SI  - GEO/GSE13417
PT  - Journal Article
DEP - 20130529
PL  - United States
TA  - Plant Cell Environ
JT  - Plant, cell & environment
JID - 9309004
RN  - 0 (Iron-Sulfur Proteins)
RN  - 0 (Plant Proteins)
RN  - EC 1.12.- (iron hydrogenase)
RN  - EC 1.12.7.2 (Hydrogenase)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adaptation, Physiological
MH  - Arabidopsis/enzymology/genetics/physiology
MH  - Carbohydrate Metabolism
MH  - Cell Cycle
MH  - Down-Regulation
MH  - Energy Metabolism
MH  - *Gene Expression Regulation, Enzymologic
MH  - Gene Expression Regulation, Plant
MH  - Hydrogenase/*genetics/metabolism
MH  - Iron-Sulfur Proteins/*genetics/metabolism
MH  - Medicago truncatula/*enzymology/genetics/physiology
MH  - Metabolomics
MH  - Mutation
MH  - Oxygen/*metabolism
MH  - Phenotype
MH  - Plant Leaves/enzymology/genetics/physiology
MH  - Plant Proteins/genetics/metabolism
MH  - Plants, Genetically Modified
MH  - Seedlings/enzymology/genetics/physiology
MH  - Stress, Physiological
MH  - Transcriptome
MH  - Up-Regulation
OTO - NOTNLM
OT  - Arabidopsis
OT  - HIF-1alpha
OT  - IOP
OT  - Medicago
OT  - NAR1
OT  - Warburg effect
OT  - oxygen
EDAT- 2013/05/04 06:00
MHDA- 2014/07/17 06:00
CRDT- 2013/05/04 06:00
PHST- 2013/02/11 00:00 [received]
PHST- 2013/04/22 00:00 [revised]
PHST- 2013/04/23 00:00 [accepted]
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2014/07/17 06:00 [medline]
AID - 10.1111/pce.12128 [doi]
PST - ppublish
SO  - Plant Cell Environ. 2014 Jan;37(1):54-69. doi: 10.1111/pce.12128. Epub 2013 May 
      29.