PMID- 23639340
OWN - NLM
STAT- MEDLINE
DCOM- 20140214
LR  - 20161125
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 77
IP  - 6
DP  - 2013 Jun
TI  - Salivary endoscopy in a pediatric patient with HLA-B27 seropositivity and 
      recurrent submandibular sialadenitis.
PG  - 1045-7
LID - S0165-5876(13)00127-4 [pii]
LID - 10.1016/j.ijporl.2013.03.027 [doi]
AB  - Patients with human leukocyte antigen (HLA)-B27 seropositivity have a genetic 
      predisposition to form spondyloarthropathies, especially ankylosing spondylitis. 
      Other related inflammatory or autoimmune disorders include reactive arthritis, 
      uveitis, psoriatic arthritis, and Crohn's disease. Although juvenile recurrent 
      parotitis is not uncommon, recurrent submandibular sialadenitis is rare in 
      pediatric patients. Sialadenitis is typically caused by salivary stones, 
      infection, or duct stricture. To our knowledge, there has not been report of 
      HLA-B27 positivity and recurrent sialadenitis described previously. We describe a 
      patient with HLA-B27 seropositivity and multiple episodes of left submandibular 
      sialadenitis who underwent diagnostic and therapeutic sialendoscopy. Previous 
      treatment included antibiotics, sialogogues, warm compresses, and hydration 
      before he underwent definitive sialendoscopy treatment at a tertiary care medical 
      center. Salivary endoscopy showed salivary stasis and sludging within the left 
      submandibular gland duct, with no salivary stones. Topical steroid was applied to 
      the duct. At one year following his surgery, he has not had any recurrent 
      episodes of sialadenitis. HLA-B27 seropositivity is associated with many 
      inflammatory disorders; we report a case in which the patient had coexisting 
      recurrent sialadenitis. In the pediatric population, sialadenitis is 
      traditionally managed with antibiotics and supportive care, however our patient 
      underwent salivary endoscopy. Sialendoscopy is an emerging modality that 
      potentially avoids radiation exposure from CT or sialography and should be 
      considered as another preferred treatment option. More investigation is required 
      to prove a possible correlation between existing HLA-B27 and the propensity to 
      develop this clinical problem.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Nguyen, Amy M
AU  - Nguyen AM
AD  - Department of Otolaryngology-Head and Neck Surgery, Kansas University Medical 
      Center, Kansas City, KS 66160, USA. anguyen@kumc.edu
FAU - Francis, Carrie L
AU  - Francis CL
FAU - Larsen, Christopher G
AU  - Larsen CG
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130429
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Child
MH  - Endoscopy/*methods
MH  - Follow-Up Studies
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
MH  - Male
MH  - Recurrence
MH  - Risk Assessment
MH  - Serologic Tests
MH  - Severity of Illness Index
MH  - Sialadenitis/diagnostic imaging/*immunology/*surgery
MH  - Submandibular Gland/diagnostic imaging/physiopathology
MH  - Tomography, X-Ray Computed/methods
MH  - Treatment Outcome
EDAT- 2013/05/04 06:00
MHDA- 2014/02/15 06:00
CRDT- 2013/05/04 06:00
PHST- 2013/01/03 00:00 [received]
PHST- 2013/03/19 00:00 [revised]
PHST- 2013/03/22 00:00 [accepted]
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2014/02/15 06:00 [medline]
AID - S0165-5876(13)00127-4 [pii]
AID - 10.1016/j.ijporl.2013.03.027 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2013 Jun;77(6):1045-7. doi: 
      10.1016/j.ijporl.2013.03.027. Epub 2013 Apr 29.