PMID- 23639363
OWN - NLM
STAT- MEDLINE
DCOM- 20140107
LR  - 20130528
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 148
IP  - 1
DP  - 2013 Jun 21
TI  - Canna indica L. attenuates high-glucose- and lipopolysaccharide-induced 
      inflammatory mediators in monocyte/macrophage.
PG  - 317-21
LID - S0378-8741(13)00302-4 [pii]
LID - 10.1016/j.jep.2013.04.037 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Canna indica L. (CI) has been widely used as a 
      folklore medicine in tropical and subtropical areas with beneficial effects in 
      numerous diseases, including infection, rheumatism, hepatitis, and it has also 
      been identified as an antioxidant. MATERIALS AND METHODS: The present study aimed 
      to investigate the effect of Canna indica CI ethanolic extract (CIE) on 
      productions of nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin-1beta 
      (IL-1beta) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. In addition, 
      the effects of CIE in high glucose (HG)-induced U937 monocytes on mRNA 
      expressions of IL-8 and monocyte chemoattractant protein-1 (MCP-1), and 
      regulation of mitogen-activated protein kinase (MAPK) pathways were also 
      identified. RESULTS: CIE was found to inhibit the production of inflammatory 
      mediators including NO, IL-1beta, and PGE2 from LPS-induced RAW 264.7 macrophages. 
      The increases in HG-induced mRNA expressions of IL-8 and MCP-1 were also 
      significantly inhibited by CIE. Stimulation of HG in U937 monocytes resulted in 
      activation of p38 MAPK, ERK1/2, and JNK. However, CIE treatment significantly 
      decreased phosphorylation of p38 MAPK, ERK1/2, and JNK. CONCLUSION: The present 
      study demonstrated that CIE suppressed the LPS-induced inflammatory mediator 
      production and also inhibited HG-induced inflammatory mediator expression by the 
      regulation of MAPK pathway.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Chen, Heng Jung
AU  - Chen HJ
AD  - Department of Food Science, National Chiayi University, 300 University Road, 
      Chia-Yi 60004, Taiwan, ROC.
FAU - Chen, Cheng-Nan
AU  - Chen CN
FAU - Sung, Mao-Lin
AU  - Sung ML
FAU - Wu, Yi-Chien
AU  - Wu YC
FAU - Ko, Pei-Ling
AU  - Ko PL
FAU - Tso, Tim K
AU  - Tso TK
LA  - eng
PT  - Journal Article
DEP - 20130429
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Interleukin-1beta)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Plant Extracts)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - IY9XDZ35W2 (Glucose)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Dinoprostone/metabolism
MH  - Glucose
MH  - Humans
MH  - Interleukin-1beta/metabolism
MH  - Lipopolysaccharides
MH  - Macrophages/*drug effects/metabolism
MH  - Mice
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Nitric Oxide/metabolism
MH  - Plant Extracts/*pharmacology
MH  - U937 Cells
MH  - *Zingiberales
EDAT- 2013/05/04 06:00
MHDA- 2014/01/08 06:00
CRDT- 2013/05/04 06:00
PHST- 2012/11/29 00:00 [received]
PHST- 2013/02/28 00:00 [revised]
PHST- 2013/04/18 00:00 [accepted]
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2014/01/08 06:00 [medline]
AID - S0378-8741(13)00302-4 [pii]
AID - 10.1016/j.jep.2013.04.037 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2013 Jun 21;148(1):317-21. doi: 10.1016/j.jep.2013.04.037. Epub 
      2013 Apr 29.