PMID- 2363941
OWN - NLM
STAT- MEDLINE
DCOM- 19900815
LR  - 20190903
IS  - 0284-186X (Print)
IS  - 0284-186X (Linking)
VI  - 29
IP  - 3
DP  - 1990
TI  - Methyl-GAG, ifosfamide, methotrexate and etoposide (MIME) as salvage therapy for 
      Hodgkin's disease and non-Hodgkin's lymphoma. The Swedish Lymphoma Study Group.
PG  - 297-301
AB  - One hundred and three patients with recurrent or refractory Hodgkin's disease 
      (HD) or non-Hodgkin's lymphoma (NHL) treated with MIME (methyl-GAG, ifosfamide, 
      methotrexate, etoposide) were retrospectively studied. Thirty-seven of the 44 
      patients with HD, 34/47 with high-grade malignant and 9/12 with low-grade 
      malignant NHL were evaluable for response. Of the 37 evaluable patients with HD, 
      16 (43%) achieved complete remission (CR) and 4 partial remission (PR), giving a 
      total response rate of 54%. Of the 34 evaluable patients with high-grade NHL, 5 
      achieved CR and 8 PR, giving a response rate of 38%. Of 9 evaluable patients with 
      low-grade NHL, 2 achieved CR. The main toxicity was leukopenia, thrombocytopenia 
      and infections. Twenty-six per cent of the patients developed septicaemia, which 
      was fatal in 6 cases (6%). We conclude that MIME as salvage regimen can induce 
      complete remissions in lymphoma patients, particularly in HD with previous heavy 
      treatment, and that it is relatively well tolerated.
FAU - Enblad, G
AU  - Enblad G
AD  - Departments of Oncology, University of Uppsala, Akademiska Hospital, Sweden.
FAU - Glimelius, B
AU  - Glimelius B
FAU - Hagberg, H
AU  - Hagberg H
FAU - Lindemalm, C
AU  - Lindemalm C
LA  - eng
PT  - Journal Article
PL  - Sweden
TA  - Acta Oncol
JT  - Acta oncologica (Stockholm, Sweden)
JID - 8709065
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - OD5Q0L447W (Mitoguazone)
RN  - UM20QQM95Y (Ifosfamide)
RN  - YL5FZ2Y5U1 (Methotrexate)
RN  - MIME protocol
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use
MH  - Etoposide/administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Hodgkin Disease/*drug therapy
MH  - Humans
MH  - Ifosfamide/administration & dosage
MH  - Lymphoma, Non-Hodgkin/*drug therapy
MH  - Male
MH  - Methotrexate/administration & dosage
MH  - Middle Aged
MH  - Mitoguazone/administration & dosage
MH  - Recurrence
MH  - Remission Induction
MH  - Retrospective Studies
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.3109/02841869009090001 [doi]
PST - ppublish
SO  - Acta Oncol. 1990;29(3):297-301. doi: 10.3109/02841869009090001.