PMID- 23639570
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20181217
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 39
IP  - 6
DP  - 2013 Dec
TI  - The association of type 2 diabetes and insulin resistance/secretion with 
      persistent organic pollutants in two First Nations communities in northern 
      Ontario.
PG  - 497-504
LID - S1262-3636(13)00033-5 [pii]
LID - 10.1016/j.diabet.2013.01.006 [doi]
AB  - AIMS: Recent evidence suggests an association between persistent organic 
      pollutants (POPs) and type 2 diabetes. In two First Nations communities where 
      wild food is consumed by a large portion of the population, we compared 
      pollutants in plasma between diabetic and non-diabetic individuals, and 
      investigated the strength of association between pollutants and insulin 
      resistance/secretion in non-diabetic individuals. METHODS: The study population 
      consisted of 72 participants. Oral Glucose Tolerance Tests were used to assess 
      diabetes status. Plasma was used to determine POP concentrations and mercury 
      concentrations were determined from hair samples. RESULTS: Age-adjusted plasma 
      concentrations of some pollutants were significantly higher in diabetic than in 
      non-diabetic individuals. When taking into account age, adiposity levels, and 
      smoking status, POP levels were not associated with insulin resistance nor with 
      insulin secretion in non-diabetic individuals. CONCLUSIONS: These findings 
      confirm that POP concentrations in plasma may be higher in diabetic than in 
      non-diabetic individuals. No association was however seen between POP 
      concentrations and markers of insulin resistance/secretion in non-diabetic 
      individuals.
CI  - Copyright (c) 2013 Elsevier Masson SAS. All rights reserved.
FAU - Pal, S
AU  - Pal S
AD  - Department of Biology, University of Ottawa, 30, Marie Curie, K1N 6N5 Ottawa, 
      Ontario, Canada.
FAU - Blais, J M
AU  - Blais JM
FAU - Robidoux, M A
AU  - Robidoux MA
FAU - Haman, F
AU  - Haman F
FAU - Krummel, E
AU  - Krummel E
FAU - Seabert, T A
AU  - Seabert TA
FAU - Imbeault, P
AU  - Imbeault P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130429
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 0 (Environmental Pollutants)
RN  - 0 (Insulin)
RN  - 0 (Pesticides)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Causality
MH  - Diabetes Mellitus, Type 2/*blood/*ethnology
MH  - Environmental Monitoring/*statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Food Contamination/*statistics & numerical data
MH  - Humans
MH  - Indians, North American/*statistics & numerical data
MH  - Insulin/metabolism
MH  - Insulin Resistance/*ethnology
MH  - Insulin Secretion
MH  - Male
MH  - Mercury/blood
MH  - Obesity/ethnology
MH  - Ontario/epidemiology
MH  - Pesticides/blood
MH  - Sex Distribution
OTO - NOTNLM
OT  - Diabetes
OT  - Diabetes
OT  - First Nation
OT  - Inflammation
OT  - Insulin resistance
OT  - Persistent organic pollutants
OT  - Polluants organiques persistants
OT  - Premieres Nations
EDAT- 2013/05/04 06:00
MHDA- 2014/06/18 06:00
CRDT- 2013/05/04 06:00
PHST- 2012/08/20 00:00 [received]
PHST- 2013/01/11 00:00 [revised]
PHST- 2013/01/11 00:00 [accepted]
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
AID - S1262-3636(13)00033-5 [pii]
AID - 10.1016/j.diabet.2013.01.006 [doi]
PST - ppublish
SO  - Diabetes Metab. 2013 Dec;39(6):497-504. doi: 10.1016/j.diabet.2013.01.006. Epub 
      2013 Apr 29.