PMID- 23639745
OWN - NLM
STAT- MEDLINE
DCOM- 20160331
LR  - 20181202
IS  - 2212-1692 (Electronic)
IS  - 1875-9572 (Linking)
VI  - 56
IP  - 4
DP  - 2015 Aug
TI  - A Newborn with Congenital Mixed Phenotype Acute Leukemia After In Vitro 
      Fertilization.
PG  - 271-4
LID - S1875-9572(13)00068-5 [pii]
LID - 10.1016/j.pedneo.2013.03.016 [doi]
AB  - Congenital leukemia is a rare disease. The majority of cases of this disease are 
      acute myelogenous leukemia (AML). Congenital acute lymphoblastic leukemia (ALL) 
      is rare and most often is of B cell lineage. Rarely, some cases have been 
      designated biphenotypic or mixed phenotype acute leukemia (MPAL). Herein, we 
      report a preterm newborn referred to us as a result of the appearance of 
      blue-violaceous dermal nodules on her body at birth. She was a twin and the 
      product of an in vitro fertilization (IVF) pregnancy. Physical examination showed 
      jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to 
      dermal nodules. Bone marrow aspiration showed 40% blasts of lymphoid lineage; 
      skin biopsy and its immunohistochemistry revealed myeloblastic infiltration of 
      the dermis. Cytogenetic analysis (46,XX), fluorescence in situ hybridization 
      (FISH) analysis, and cranial magnetic resonance were normal. The patient was 
      diagnosed with congenital MPAL, and an association between IVF and congenital 
      leukemia was suggested.
CI  - Copyright (c) 2013. Published by Elsevier B.V.
FAU - Ergin, Hacer
AU  - Ergin H
AD  - Department of Pediatrics, Faculty of Medicine, Pamukkale University, Denizli, 
      Turkey.
FAU - Ozdemir, Ozmert M A
AU  - Ozdemir OM
AD  - Department of Pediatrics, Faculty of Medicine, Pamukkale University, Denizli, 
      Turkey. Electronic address: drozmert@gmail.com.
FAU - Karaca, Abdullah
AU  - Karaca A
AD  - Department of Pediatrics, Faculty of Medicine, Pamukkale University, Denizli, 
      Turkey.
FAU - Turk, Nilay Sen
AU  - Turk NS
AD  - Department of Pathology, Faculty of Medicine, Pamukkale University, Denizli, 
      Turkey.
FAU - Duzcan, Fusun
AU  - Duzcan F
AD  - Department of Clinical Genetics, Faculty of Medicine, Pamukkale University, 
      Denizli, Turkey.
FAU - Ergin, Seniz
AU  - Ergin S
AD  - Department of Dermatology, Faculty of Medicine, Pamukkale University, Denizli, 
      Turkey.
FAU - Kazanci, Elif
AU  - Kazanci E
AD  - Department of Pediatric Hematology-Oncology, Behcet Uz Pediatric Hospital, Izmir, 
      Turkey.
FAU - Vergin, Canan
AU  - Vergin C
AD  - Department of Pediatric Hematology-Oncology, Behcet Uz Pediatric Hospital, Izmir, 
      Turkey.
FAU - Erbay, Ayse
AU  - Erbay A
AD  - Department of Pediatric Hematology-Oncology, Behcet Uz Pediatric Hospital, Izmir, 
      Turkey.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130430
PL  - Singapore
TA  - Pediatr Neonatol
JT  - Pediatrics and neonatology
JID - 101484755
SB  - IM
MH  - Diseases in Twins/*genetics/immunology
MH  - Female
MH  - Fertilization in Vitro/*adverse effects
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Infant, Newborn
MH  - Infant, Premature
MH  - Leukemia, Biphenotypic, Acute/*congenital/immunology
MH  - Skin Neoplasms/*congenital/immunology
OTO - NOTNLM
OT  - congenital
OT  - in vitro fertilization (IVF)
OT  - leukemia cutis
OT  - mixed phenotype acute leukemia (MPAL)
EDAT- 2013/05/04 06:00
MHDA- 2016/04/01 06:00
CRDT- 2013/05/04 06:00
PHST- 2012/07/03 00:00 [received]
PHST- 2012/10/23 00:00 [revised]
PHST- 2013/03/28 00:00 [accepted]
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2016/04/01 06:00 [medline]
AID - S1875-9572(13)00068-5 [pii]
AID - 10.1016/j.pedneo.2013.03.016 [doi]
PST - ppublish
SO  - Pediatr Neonatol. 2015 Aug;56(4):271-4. doi: 10.1016/j.pedneo.2013.03.016. Epub 
      2013 Apr 30.