PMID- 23639831
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20211021
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Print)
IS  - 1044-7431 (Linking)
VI  - 56
DP  - 2013 Sep
TI  - Neurotrophin and Wnt signaling cooperatively regulate dendritic spine formation.
PG  - 115-27
LID - S1044-7431(13)00054-7 [pii]
LID - 10.1016/j.mcn.2013.04.006 [doi]
AB  - Dendritic spines are major sites of excitatory synaptic transmission and changes 
      in their numbers and morphology have been associated with neurodevelopmental and 
      neurodegenerative disorders. Brain-derived Neurotrophic Factor (BDNF) is a 
      secreted growth factor that influences hippocampal, striatal and neocortical 
      pyramidal neuron dendritic spine density. However, the mechanisms by which BDNF 
      regulates dendritic spines and how BDNF interacts with other regulators of spines 
      remain unclear. We propose that one mechanism by which BDNF promotes dendritic 
      spine formation is through an interaction with Wnt signaling. Here, we show that 
      Wnt signaling inhibition in cultured cortical neurons disrupts dendritic spine 
      development, reduces dendritic arbor size and complexity, and blocks BDNF-induced 
      dendritic spine formation and maturation. Additionally, we show that BDNF 
      regulates expression of Wnt2, and that Wnt2 is sufficient to promote cortical 
      dendrite growth and dendritic spine formation. Together, these data suggest that 
      BDNF and Wnt signaling cooperatively regulate dendritic spine formation.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Hiester, Brian G
AU  - Hiester BG
AD  - Department of Molecular, Cellular and Developmental Biology, 347 UCB, University 
      of Colorado, Boulder, CO 80309, United States.
FAU - Galati, Domenico F
AU  - Galati DF
FAU - Salinas, Patricia C
AU  - Salinas PC
FAU - Jones, Kevin R
AU  - Jones KR
LA  - eng
GR  - G0802241/MRC_/Medical Research Council/United Kingdom
GR  - MR/J013374/1/MRC_/Medical Research Council/United Kingdom
GR  - R01 EY014998/EY/NEI NIH HHS/United States
GR  - R01 EY14998/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130430
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Wnt2 Protein)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cell Growth Processes
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology/metabolism
MH  - Dendritic Spines/*metabolism/physiology
MH  - Mice
MH  - *Wnt Signaling Pathway
MH  - Wnt2 Protein/genetics/metabolism
PMC - PMC3793870
OTO - NOTNLM
OT  - BDNF
OT  - Dendrite branching
OT  - Dendritic spine
OT  - Synapse
OT  - Wnt signaling
EDAT- 2013/05/04 06:00
MHDA- 2014/06/21 06:00
PMCR- 2013/09/01
CRDT- 2013/05/04 06:00
PHST- 2012/06/16 00:00 [received]
PHST- 2013/04/20 00:00 [revised]
PHST- 2013/04/23 00:00 [accepted]
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - S1044-7431(13)00054-7 [pii]
AID - 10.1016/j.mcn.2013.04.006 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 2013 Sep;56:115-27. doi: 10.1016/j.mcn.2013.04.006. Epub 2013 
      Apr 30.