PMID- 23640243
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20190109
IS  - 1532-8651 (Electronic)
IS  - 1098-7339 (Linking)
VI  - 38
IP  - 4
DP  - 2013 Jul-Aug
TI  - Exercise training attenuates postoperative pain and expression of cytokines and 
      N-methyl-D-aspartate receptor subunit 1 in rats.
PG  - 282-8
LID - 10.1097/AAP.0b013e31828df3f9 [doi]
AB  - BACKGROUND: Exercise creates a variety of psychophysical effects, including 
      altered pain perception. We investigated whether physical exercise reduces 
      postincisional pain and cytokine and N-methyl-D-aspartate receptor 1 (NR1) 
      expression in a rat model of skin/muscle incision and retraction (SMIR)-evoked 
      pain. METHODS: Male Sprague-Dawley rats were divided randomly into 4 groups: sham 
      operated, SMIR-sedentary (SS), SMIR-exercise, and sham operated-exercise. On 
      postoperative day 8, trained rats started to run on a treadmill 55 min/d with an 
      intensity of 18 meter/minute (m/min), 5 days per week for 4 weeks. NR1, tumor 
      necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) expressions in the spinal 
      cord as well as mechanical hypersensitivity following SMIR surgery were assessed 
      for 6 to 35 days. RESULTS: On postoperative day 6, SMIR-sedentary rats exhibited 
      a marked hypersensitivity to von Frey stimuli. By contrast, SMIR-operated rats 
      undergoing exercise demonstrated a quick recovery of mechanical hypersensitivity. 
      The levels of TNF-alpha, IL-6, and NR1 in the spinal cord were significantly 
      increased in SS rats when compared with sham-operated rats on postoperative days 
      6, 21, and 35 after SMIR surgery. After the 4-week exercise intervention, the 
      SMIR-exercise group showed lower NR1, TNF-alpha, and IL-6 expression in the spinal 
      cord than those in the SS group. CONCLUSIONS: These results suggest that exercise 
      training decreases persistent postsurgical pain caused by SMIR surgery. There 
      appears to be a protective effect, probably relating to the decrease of NR1, 
      TNF-alpha, and IL-6 expression in the spinal cord of SMIR rats, after exercise 
      intervention.
FAU - Chen, Yu-Wen
AU  - Chen YW
AD  - Department of Physical Therapy, China Medical University, Taichung, Taiwan.
FAU - Lin, Min-Fei
AU  - Lin MF
FAU - Chen, Yu-Chung
AU  - Chen YC
FAU - Hung, Ching-Hsia
AU  - Hung CH
FAU - Tzeng, Jann-Inn
AU  - Tzeng JI
FAU - Wang, Jhi-Joung
AU  - Wang JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Reg Anesth Pain Med
JT  - Regional anesthesia and pain medicine
JID - 9804508
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (NMDA receptor A1)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Cytokines/*metabolism
MH  - Disease Models, Animal
MH  - Down-Regulation
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Pain Measurement
MH  - *Pain Perception
MH  - *Pain Threshold
MH  - Pain, Postoperative/metabolism/physiopathology/*prevention & control/psychology
MH  - *Physical Exertion
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Running
MH  - Spinal Cord/*metabolism/physiopathology
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2013/05/04 06:00
MHDA- 2014/03/04 06:00
CRDT- 2013/05/04 06:00
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
AID - 10.1097/AAP.0b013e31828df3f9 [doi]
PST - ppublish
SO  - Reg Anesth Pain Med. 2013 Jul-Aug;38(4):282-8. doi: 10.1097/AAP.0b013e31828df3f9.