PMID- 23640807
OWN - NLM
STAT- MEDLINE
DCOM- 20140210
LR  - 20130626
IS  - 1098-1136 (Electronic)
IS  - 0894-1491 (Linking)
VI  - 61
IP  - 7
DP  - 2013 Jul
TI  - Brain-derived neurotrophic factor/TrkB signaling regulates daily astroglial 
      plasticity in the suprachiasmatic nucleus: electron-microscopic evidence in 
      mouse.
PG  - 1172-7
LID - 10.1002/glia.22509 [doi]
AB  - Synchronization of circadian rhythms to the 24-h light/dark (L/D) cycle is 
      associated with daily rearrangements of the neuronal-glial network of the 
      suprachiasmatic nucleus of the hypothalamus (SCN), the central master clock 
      orchestrating biological functions in mammals. These anatomical plastic events 
      involve neurons synthesizing vasoactive intestinal peptide (VIP), known as major 
      integrators of photic signals in the retinorecipient region of the SCN. Using an 
      analog-sensitive kinase allele murine model (TrkB(F616A) ), we presently show 
      that the pharmacological blockade of the tropomyosin-related kinase receptor type 
      B (TrkB), the high-affinity receptor of brain-derived neurotrophic factor (BDNF), 
      abolished day/night changes in the dendrite enwrapping of VIP neurons by 
      astrocytic processes (glial coverage), used as an index of SCN plasticity on 
      electron-microscopic sections. Therefore, the BDNF/TrkB signaling pathway exerts 
      a permissive role on the ultrastructural rearrangements that occur in SCN under 
      L/D alternance, an action that could be a critical determinant of the 
      well-established role played by BDNF in the photic regulation of the SCN. In 
      contrast, the extent of glial coverage of non-VIP neighboring dendrites was not 
      different at daytime and nighttime in TrkB(F616A) mice submitted to TrkB 
      inactivation or not receiving any pharmacological treatment. These data not only 
      show that BDNF regulates SCN structural plasticity across the 24-h cycle but also 
      reinforce the view that the daily changes in SCN architecture subserve the light 
      synchronization process.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Girardet, Clemence
AU  - Girardet C
AD  - Aix Marseille Universite, CNRS, CRN2M UMR7286, Faculte de Medecine, 13344 cedex 
      15, Marseille, France.
FAU - Lebrun, Bruno
AU  - Lebrun B
FAU - Cabirol-Pol, Marie-Jeanne
AU  - Cabirol-Pol MJ
FAU - Tardivel, Catherine
AU  - Tardivel C
FAU - Francois-Bellan, Anne-Marie
AU  - Francois-Bellan AM
FAU - Becquet, Denis
AU  - Becquet D
FAU - Bosler, Olivier
AU  - Bosler O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130502
PL  - United States
TA  - Glia
JT  - Glia
JID - 8806785
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 47E5O17Y3R (Phenylalanine)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Alanine/genetics
MH  - Analysis of Variance
MH  - Animals
MH  - Astrocytes/*metabolism/*ultrastructure
MH  - Brain-Derived Neurotrophic Factor/*metabolism/ultrastructure
MH  - Circadian Rhythm/physiology
MH  - Dendrites/metabolism/ultrastructure
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Microscopy, Immunoelectron
MH  - Mutation/genetics
MH  - Phenylalanine/genetics
MH  - Receptor, trkB/genetics/*metabolism/ultrastructure
MH  - Signal Transduction/genetics/*physiology
MH  - Suprachiasmatic Nucleus/*cytology
MH  - Vasoactive Intestinal Peptide/metabolism
EDAT- 2013/05/04 06:00
MHDA- 2014/02/11 06:00
CRDT- 2013/05/04 06:00
PHST- 2012/11/26 00:00 [received]
PHST- 2013/03/20 00:00 [accepted]
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2014/02/11 06:00 [medline]
AID - 10.1002/glia.22509 [doi]
PST - ppublish
SO  - Glia. 2013 Jul;61(7):1172-7. doi: 10.1002/glia.22509. Epub 2013 May 2.