PMID- 23640842
OWN - NLM
STAT- MEDLINE
DCOM- 20140409
LR  - 20211203
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Print)
IS  - 1050-9631 (Linking)
VI  - 23
IP  - 9
DP  - 2013 Sep
TI  - Memory accuracy predicts hippocampal mTOR pathway activation following retrieval 
      of contextual fear memory.
PG  - 842-7
LID - 10.1002/hipo.22140 [doi]
AB  - Prior work suggests that hippocampus-dependent memory undergoes a systems 
      consolidation process such that recent memories are stored in the hippocampus, 
      while older memories are independent of the hippocampus and instead dependent on 
      cortical areas. One problem with interpreting these studies is that memory for 
      the contextual stimuli weakens as time passes between the training event and 
      testing and older memories are often less detailed, making it difficult to 
      determine if memory storage in the hippocampus is related to the age or to the 
      accuracy of the memory. Activity of the mammalian target of rapamycin (mTOR) 
      signaling pathway is known to be important for controlling protein translation 
      necessary for both memory consolidation after initial learning and for the 
      reconsolidation of memory after retrieval. We tested whether p70s6 kinase 
      (p70s6K), a key component of the mTOR signaling pathway, is activated following 
      retrieval of context fear memory in the dorsal hippocampus (DH) and anterior 
      cingulate cortex (ACC) at 1, 10, or 36 days after context fear conditioning. We 
      also tested whether strengthening memory for the contextual stimuli changed 
      p70s6K phosphorylation in these structures 36 days after training. We show that 
      under standard training conditions retrieval of a recently formed memory is 
      initially precise and involves the DH. Over time it loses detail, becomes 
      independent of the DH and depends on the ACC. In a subsequent experiment, we 
      preserved the accuracy of older memories through pre-exposure to the training 
      context. We show that remote memory still involved the DH in animals given 
      pre-exposure. These data support the notion that detailed memories depend on the 
      DH regardless of their age.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Gafford, Georgette M
AU  - Gafford GM
AD  - Psychology Department, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
FAU - Parsons, Ryan G
AU  - Parsons RG
FAU - Helmstetter, Fred J
AU  - Helmstetter FJ
LA  - eng
GR  - R01 MH069558/MH/NIMH NIH HHS/United States
GR  - R01MH069558/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130604
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Conditioning, Psychological/*physiology
MH  - *Fear
MH  - Freezing Reaction, Cataleptic/physiology
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Mental Recall/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Ribosomal Protein S6 Kinases, 70-kDa/metabolism
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases/*metabolism
MH  - Time Factors
PMC - PMC3775923
MID - NIHMS482160
OTO - NOTNLM
OT  - context fear conditioning
OT  - fear conditioning
OT  - p70s6K
OT  - rat
OT  - remote fear memory
EDAT- 2013/05/04 06:00
MHDA- 2014/04/10 06:00
PMCR- 2014/09/01
CRDT- 2013/05/04 06:00
PHST- 2013/01/30 00:00 [received]
PHST- 2013/04/07 00:00 [revised]
PHST- 2013/04/16 00:00 [accepted]
PHST- 2013/05/04 06:00 [entrez]
PHST- 2013/05/04 06:00 [pubmed]
PHST- 2014/04/10 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - 10.1002/hipo.22140 [doi]
PST - ppublish
SO  - Hippocampus. 2013 Sep;23(9):842-7. doi: 10.1002/hipo.22140. Epub 2013 Jun 4.