PMID- 2364131
OWN - NLM
STAT- MEDLINE
DCOM- 19900813
LR  - 20041117
IS  - 0006-341X (Print)
IS  - 0006-341X (Linking)
VI  - 46
IP  - 2
DP  - 1990 Jun
TI  - Testing the Hardy-Weinberg equilibrium in the HLA system.
PG  - 415-26
AB  - A new method of testing the Hardy-Weinberg equilibrium in the human leukocyte 
      antigen (HLA) system is proposed and applied to real data. The derivation is 
      based on the maximum likelihood method and closely related to standard regression 
      theory. The test statistic has a closed representation of residual sum of squares 
      by a projection mapping of data onto the estimated regression plane. Under the 
      Hardy-Weinberg law the noniterative estimates for the gene frequencies are 
      suggested by the use of the projection mapping. The test statistic and gene 
      frequency estimates are shown to be asymptotically equivalent to the maximum 
      likelihood method and to be more efficient than the other suggested test 
      statistic when there are more than two identified alleles.
FAU - Eguchi, S
AU  - Eguchi S
AD  - Department of Mathematics, Shimane University, Matsue, Japan.
FAU - Matsuura, M
AU  - Matsuura M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Biometrics
JT  - Biometrics
JID - 0370625
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Biometry
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Likelihood Functions
MH  - Models, Statistical
MH  - Regression Analysis
EDAT- 1990/06/01 00:00
MHDA- 1990/06/01 00:01
CRDT- 1990/06/01 00:00
PHST- 1990/06/01 00:00 [pubmed]
PHST- 1990/06/01 00:01 [medline]
PHST- 1990/06/01 00:00 [entrez]
PST - ppublish
SO  - Biometrics. 1990 Jun;46(2):415-26.