PMID- 23642430
OWN - NLM
STAT- MEDLINE
DCOM- 20130822
LR  - 20200413
IS  - 1678-4782 (Electronic)
IS  - 0021-7557 (Linking)
VI  - 89
IP  - 2
DP  - 2013 Mar-Apr
TI  - Risk factors and lethality of laboratory-confirmed bloodstream infection caused 
      by non-skin contaminant pathogens in neonates.
PG  - 189-96
LID - S0021-7557(13)00019-3 [pii]
LID - 10.1016/j.jped.2013.03.002 [doi]
AB  - OBJECTIVE: To evaluate risk factors and lethality of late onset 
      laboratory-confirmed bloodstream infection (LCBI) in a Brazilian neonatal unit 
      for progressive care (NUPC). METHODS: This was a case-control study, performed 
      from 2008 to 2012. Cases were defined as all newborns with late onset LCBI, 
      excluding patients with isolated common skin contaminants. Controls were newborns 
      who showed no evidence of late onset LCBI, matched by weight and time of 
      permanence in the NUPC. Variables were obtained in the Hospital Infection Control 
      Committee (HICC) database. Analysis was performed using the Statistical Package 
      for the Social Sciences (SPSS). The chi-squared test was used, and statistical 
      significance was defined as p < 0.05, followed by multivariate analysis. RESULTS: 
      50 patients with late onset LCBI were matched with 100 patients without late 
      onset LCBI. In the group of patients with late onset LCBI, a significant higher 
      proportion of patients who underwent surgical procedures (p = 0.001) and who used 
      central venous catheter (CVC) (p = 0.012) and mechanical ventilation (p = 0.001) 
      was identified. In multivariate analysis, previous surgery and the use of CVC 
      remained significantly associated with infection (p = 0.006 and p = 0.047; OR: 
      4.47 and 8.99, respectively). Enterobacteriacea was identified in 14 cases, with 
      three (21.4%) deaths, and Staphylococcus aureus was identified in 20 cases, with 
      three (15%) deaths. CONCLUSIONS: Surgical procedures and CVC usage were 
      significant risk factors for LCBI. Therefore, prevention practices for safe 
      surgery and CVC insertion and manipulation are essential to reduce these 
      infections, in addition to training and continuing education to surgical and 
      assistance teams.
CI  - Copyright (c) 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora 
      Ltda. All rights reserved.
FAU - Romanelli, Roberta M C
AU  - Romanelli RM
AD  - Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas 
      Gerais UFMG, Belo Horizonte, MG, Brazil. rmcromanelli@ig.com.br
FAU - Anchieta, Leni M
AU  - Anchieta LM
FAU - Mourao, Maria Vitoria A
AU  - Mourao MV
FAU - Campos, Flavia A
AU  - Campos FA
FAU - Loyola, Flavia C
AU  - Loyola FC
FAU - Mourao, Paulo Henrique O
AU  - Mourao PH
FAU - Armond, Guilherme A
AU  - Armond GA
FAU - Clemente, Wanessa T
AU  - Clemente WT
FAU - Bouzada, Maria Candida F
AU  - Bouzada MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - J Pediatr (Rio J)
JT  - Jornal de pediatria
JID - 2985188R
SB  - IM
MH  - Catheter-Related Infections/prevention & control
MH  - Central Venous Catheters/*microbiology
MH  - Cross Infection/*microbiology/mortality
MH  - Digestive System Surgical Procedures/*adverse effects
MH  - Enterobacteriaceae Infections/*microbiology/mortality
MH  - Epidemiologic Methods
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Intensive Care Units
MH  - Laboratories, Hospital
MH  - Male
MH  - Risk Factors
MH  - Sepsis/*microbiology/mortality
MH  - Staphylococcal Infections/*microbiology/mortality
MH  - Time Factors
EDAT- 2013/05/07 06:00
MHDA- 2013/08/24 06:00
CRDT- 2013/05/07 06:00
PHST- 2012/04/24 00:00 [received]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2013/05/07 06:00 [entrez]
PHST- 2013/05/07 06:00 [pubmed]
PHST- 2013/08/24 06:00 [medline]
AID - S0021-7557(13)00019-3 [pii]
AID - 10.1016/j.jped.2013.03.002 [doi]
PST - ppublish
SO  - J Pediatr (Rio J). 2013 Mar-Apr;89(2):189-96. doi: 10.1016/j.jped.2013.03.002.