PMID- 23643837
OWN - NLM
STAT- MEDLINE
DCOM- 20131212
LR  - 20211021
IS  - 1879-0445 (Electronic)
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 23
IP  - 10
DP  - 2013 May 20
TI  - Metabolic regulation of brain response to food cues.
PG  - 878-83
LID - S0960-9822(13)00409-0 [pii]
LID - 10.1016/j.cub.2013.04.001 [doi]
AB  - Identification of energy sources depends upon the ability to form associations 
      between food cues and nutritional value. As such, cues previously paired with 
      calories elicit neuronal activation in the nucleus accumbens (NAcc), which 
      reflects the reinforcing value of food. The identity of the physiological signals 
      regulating this response remains elusive. Using fMRI, we examined brain response 
      to noncaloric versions of flavors that had been consumed in previous days with 
      either 0 or 112.5 calories from undetected maltodextrin. We report a small but 
      perceptually meaningful increase in liking for the flavor that had been paired 
      with calories and find that change in liking was associated with changes in 
      insular responses to this beverage. In contrast, NAcc and hypothalamic response 
      to the calorie-paired flavor was unrelated to liking but was strongly associated 
      with the changes in plasma glucose levels produced by ingestion of the beverage 
      when consumed previously with calories. Importantly, because each participant 
      ingested the same caloric dose, the change in plasma glucose depended upon 
      individual differences in glucose metabolism. We conclude that glucose metabolism 
      is a critical signal regulating NAcc and hypothalamic response to food cues, and 
      that this process operates independently from the ability of calories to 
      condition liking.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - de Araujo, Ivan E
AU  - de Araujo IE
AD  - The John B. Pierce Laboratory, New Haven, CT 06519, USA. iaraujo@jbpierce.org
FAU - Lin, Tammy
AU  - Lin T
FAU - Veldhuizen, Maria G
AU  - Veldhuizen MG
FAU - Small, Dana M
AU  - Small DM
LA  - eng
GR  - R01 DC009997/DC/NIDCD NIH HHS/United States
GR  - R01 DK085579/DK/NIDDK NIH HHS/United States
GR  - R01-DC009997/DC/NIDCD NIH HHS/United States
GR  - R01-DK085579/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130502
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Blood Glucose)
RN  - 0 (Polysaccharides)
RN  - 7CVR7L4A2D (maltodextrin)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - *Feeding Behavior
MH  - Hypothalamus/metabolism/*physiology
MH  - Magnetic Resonance Imaging
MH  - Nucleus Accumbens/metabolism/*physiology
MH  - Polysaccharides/administration & dosage
PMC - PMC3767438
MID - NIHMS463947
EDAT- 2013/05/07 06:00
MHDA- 2013/12/18 06:00
PMCR- 2014/05/20
CRDT- 2013/05/07 06:00
PHST- 2013/01/28 00:00 [received]
PHST- 2013/03/06 00:00 [revised]
PHST- 2013/04/02 00:00 [accepted]
PHST- 2013/05/07 06:00 [entrez]
PHST- 2013/05/07 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PHST- 2014/05/20 00:00 [pmc-release]
AID - S0960-9822(13)00409-0 [pii]
AID - 10.1016/j.cub.2013.04.001 [doi]
PST - ppublish
SO  - Curr Biol. 2013 May 20;23(10):878-83. doi: 10.1016/j.cub.2013.04.001. Epub 2013 
      May 2.