PMID- 23643991
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20180816
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 545
DP  - 2013 Jun 17
TI  - Lack of association between brain-derived neurotrophic factor Val66Met 
      polymorphism and body mass index change over time in healthy adults.
PG  - 127-31
LID - S0304-3940(13)00395-9 [pii]
LID - 10.1016/j.neulet.2013.04.036 [doi]
AB  - Obesity is becoming the epidemic health problem worldwide with a very complex 
      etiology. The interaction between diverse genetic and environmental factors 
      contributes to development of obesity. Among myriad of functions in central and 
      peripheral tissues, brain-derived neurotrophic factor (BDNF) also regulates 
      energy homeostasis, food intake and feeding behavior, and has a role in obesity 
      and increased body mass index (BMI). BDNF Val66Met (rs6265) polymorphism is 
      associated with BMI gain, but both positive associations and non-replications are 
      reported. Since BMI changes over time and since genetic influences on BMI vary 
      with age, the aim of the study was to evaluate association between BDNF Val66Met 
      polymorphism and BMI gain in healthy subjects with middle or old age. The study 
      included a cohort of 339 adult healthy Caucasians of Croatian origin, free of 
      eating and metabolic disorders, evaluated in three time periods in the year 1972, 
      1982 and 2006, when the subjects were around 40, 50 and 70 years old, 
      respectively. The results revealed a significant effect of smoking on BMI, but a 
      lack of significant association between BDNF Val66Met polymorphism and overweight 
      or obesity, and no significant association between BDNF Val66Met and BMI changes 
      over time. These results did not confirm the major role of BDNF Val66Met in the 
      regulation of BMI changes in adult and old healthy subjects.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Nikolac Perkovic, Matea
AU  - Nikolac Perkovic M
AD  - Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, HR-10000 
      Zagreb, Croatia.
FAU - Mustapic, Maja
AU  - Mustapic M
FAU - Pavlovic, Mladen
AU  - Pavlovic M
FAU - Uzun, Suzana
AU  - Uzun S
FAU - Kozumplik, Oliver
AU  - Kozumplik O
FAU - Barisic, Ivan
AU  - Barisic I
FAU - Muck-Seler, Dorotea
AU  - Muck-Seler D
FAU - Pivac, Nela
AU  - Pivac N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130502
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - *Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Comorbidity
MH  - Croatia/epidemiology
MH  - Female
MH  - Genetic Predisposition to Disease/*epidemiology/*genetics
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*epidemiology/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Prevalence
MH  - Risk Factors
MH  - Statistics as Topic
EDAT- 2013/05/07 06:00
MHDA- 2014/01/07 06:00
CRDT- 2013/05/07 06:00
PHST- 2013/02/27 00:00 [received]
PHST- 2013/04/12 00:00 [revised]
PHST- 2013/04/24 00:00 [accepted]
PHST- 2013/05/07 06:00 [entrez]
PHST- 2013/05/07 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
AID - S0304-3940(13)00395-9 [pii]
AID - 10.1016/j.neulet.2013.04.036 [doi]
PST - ppublish
SO  - Neurosci Lett. 2013 Jun 17;545:127-31. doi: 10.1016/j.neulet.2013.04.036. Epub 
      2013 May 2.