PMID- 23644008
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20130613
IS  - 1873-1244 (Electronic)
IS  - 0899-9007 (Linking)
VI  - 29
IP  - 7-8
DP  - 2013 Jul-Aug
TI  - Parenteral nutrition mixtures prepared at home by trained parents are as safe as 
      pharmacy-made mixtures: a 3-y prospective study.
PG  - 988-92
LID - S0899-9007(13)00082-8 [pii]
LID - 10.1016/j.nut.2013.01.014 [doi]
AB  - OBJECTIVES: Home parenteral nutrition (HPN) prevents malnutrition in children 
      with intestinal failure improving chances for the best possible physical 
      development and quality of life. For organizational reasons, in Poland the 
      majority of children on HPN receive nutrition mixtures prepared at home by their 
      parents. The aim of this study was to evaluate whether this method influences the 
      frequency of catheter-related bloodstream infections (CRBSIs). METHODS: The aim 
      of this prospective study was to assess the incidence of CRBSIs from January 2008 
      to December 2010 in 181 children on HPN and to compare the incidence in two 
      subgroups of these children: group Ph (pharmacy) consisting of 43 patients 
      receiving mixtures prepared in the hospital pharmacy weekly, and group H 
      (home)-138 patients receiving nutrition mixtures prepared daily at home by their 
      caregivers. Central venous CRBSIs were diagnosed by the presence of clinical 
      signs (such as fever, chills, malaise, vomiting) associated with positive blood 
      culture from the central catheter. RESULTS: From 2008 to 2010 parenteral 
      nutrition was administrated during 128 905 catheter-days in 181 patients, and 
      CRBSIs occurred 129 times (1 episode per 1000 catheter-days) in 65 patients. 
      There were 42 bloodstream infections in group Ph during 29 225 catheter-days 
      (i.e., 1.43 per 1000 catheter-days), whereas 87 bloodstream infections occurred 
      in group H during 100 775 catheter-days (i.e., 0.86 per 1000 catheter-days; P = 
      0.0516). CONCLUSIONS: Preparing parenteral nutrition mixtures at home by trained 
      parents is a safe method of HPN with a slightly (however insignificantly) lower 
      incidence of CRBSIs compared with hospital pharmacy-prepared parenteral nutrition 
      mixtures.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Friedman-Gruszczynska, Joanna
AU  - Friedman-Gruszczynska J
AD  - Department of Pediatrics and Nutrition, Children's Memorial Health Institute, 
      Warsaw, Poland. joanna@friedman.pl
FAU - Ossolinska, Magdalena
AU  - Ossolinska M
FAU - Popinska, Katarzyna
AU  - Popinska K
FAU - Ksiazyk, Janusz B
AU  - Ksiazyk JB
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130502
PL  - United States
TA  - Nutrition
JT  - Nutrition (Burbank, Los Angeles County, Calif.)
JID - 8802712
RN  - 0 (Parenteral Nutrition Solutions)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Catheter-Related Infections/*epidemiology/etiology/microbiology/prevention & 
      control
MH  - Catheterization, Central Venous/adverse effects
MH  - Catheters/microbiology
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Incidence
MH  - Infant
MH  - Malnutrition/prevention & control
MH  - Nutritive Value
MH  - Parenteral Nutrition Solutions/*adverse effects
MH  - Parenteral Nutrition, Home/*adverse effects
MH  - Parents/*education
MH  - Poland
MH  - Prospective Studies
MH  - Quality of Life
MH  - Risk Factors
MH  - Young Adult
EDAT- 2013/05/07 06:00
MHDA- 2014/02/05 06:00
CRDT- 2013/05/07 06:00
PHST- 2012/07/17 00:00 [received]
PHST- 2013/01/09 00:00 [revised]
PHST- 2013/01/17 00:00 [accepted]
PHST- 2013/05/07 06:00 [entrez]
PHST- 2013/05/07 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - S0899-9007(13)00082-8 [pii]
AID - 10.1016/j.nut.2013.01.014 [doi]
PST - ppublish
SO  - Nutrition. 2013 Jul-Aug;29(7-8):988-92. doi: 10.1016/j.nut.2013.01.014. Epub 2013 
      May 2.