PMID- 23644126
OWN - NLM
STAT- MEDLINE
DCOM- 20140717
LR  - 20130506
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 33
IP  - 4
DP  - 2013 Apr
TI  - [Matrix metalloproteinase-3 genotype distribution and its relation with blood 
      pressure profiles in Guangzhou rural population].
PG  - 586-9
AB  - OBJECTIVE: To analyze the distribution of matrix metalloproteinase-3 (MMP-3) 
      genotype and its association with the blood pressure profiles in Guangzhou rural 
      population. METHODS: This study was conducted among 680 rural residents aged 
      40-70 years (including 314 men and 366 women) from 3 villages in an rural area of 
      Guangzhou. The blood pressures of the subjects were measured and blood samples 
      were collected for genotype analysis using polymerase chain reaction and direct 
      sequencing of the MMP-3 gene promoter region to detect the 5 adenines (5A)/6 
      adenines (6A) polymorphisms. RESULTS: The frequencies of MMP-3 genotypes 6A/6A, 
      5A/5A, and 5A/6A were 82.6%, 1.8% and 15.6% among these residents, respectively. 
      The distribution of MMP-3 genotypes and allele frequencies showed no significant 
      gender- or age-related variations. The men with different genotypes (6A/6A vs 
      5A/6A+5A/5A) did not show significant differences in blood pressure levels, 
      whereas the women with 5A/6A+5A/5A genotypes had higher systolic and diastolic 
      blood pressures than those with a 6A/6A genotype. The allele 5A was highly 
      frequent in the hypertensive residents as compared with the normotensive 
      residents. CONCLUSIONS: The 6A homozygote is the predominant genotype of MMP-3 in 
      Guangzhou rural population, which has a significantly lower proportion of 5A 
      homozygote than the Western populations. The 5A allele is associated with a high 
      risk of hypertension especially in women and may affect both systolic and 
      diastolic blood pressures.
FAU - Shao, Yechang
AU  - Shao Y
AD  - Department of Epidemiology, Guangdong Academic of Medical Sciences/Guangdong 
      General Hospital, Guangzhou 510080, China. shaoyc888@yahoo.com.cn
FAU - Deng, Mulan
AU  - Deng M
FAU - Lian, Zibin
AU  - Lian Z
FAU - Shi, Meiling
AU  - Shi M
FAU - Jiang, Xiaxing
AU  - Jiang X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Alleles
MH  - Blood Pressure
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Hypertension/epidemiology/*genetics
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Risk Factors
MH  - *Rural Population
MH  - Sex Distribution
EDAT- 2013/05/07 06:00
MHDA- 2014/07/18 06:00
CRDT- 2013/05/07 06:00
PHST- 2013/05/07 06:00 [entrez]
PHST- 2013/05/07 06:00 [pubmed]
PHST- 2014/07/18 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2013 Apr;33(4):586-9.