PMID- 23644690
OWN - NLM
STAT- MEDLINE
DCOM- 20131231
LR  - 20190429
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 254-255
DP  - 2013 Jun 15
TI  - Dispersive liquid-liquid microextraction for the high performance liquid 
      chromatographic determination of aldehydes in cigarette smoke and injectable 
      formulations.
PG  - 390-396
LID - S0304-3894(13)00221-5 [pii]
LID - 10.1016/j.jhazmat.2013.03.034 [doi]
AB  - A dispersive liquid-liquid microextraction method (DLLME) combined with high 
      performance liquid chromatography (HPLC) was developed for the extraction and 
      determination of some aldehydes, such as benzaldehyde (BzA), butyraldehyde (BuA) 
      and furfural (Fur) in mainstream cigarette smoke as well as BzA in injectable 
      formulations. After trapping of combustion smoke into sulfuric acid with a 
      laboratory-made smoking machine, aldehydes were converted into their hydrazone 
      derivatives by the reaction with 2,4-dinitrophenylhydrazine (DNPH), and then 
      rapidly extracted by DLLME. The effects of various experimental parameters on the 
      derivatization and extraction were studied and optimized. Under the optimum 
      extraction conditions, linear calibration curves in the range 0.025 to 1.0 mug/mL 
      with correlation coefficients of 0.9980-0.9996 were obtained for studied 
      aldehydes. Limit of detections (LODs) for BzA, BuA and Fur were found to be 14.2, 
      21.3 and 7.92 mug/L, respectively. The relative standard deviations (RSDs) for 
      inter-and intra-day assays were lower than 8.50%. Average recoveries for spiked 
      samples were in the range 88.0-109%. The proposed method was successfully applied 
      to the determination of aldehydes in different real samples.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Ahad Bavili Tabrizi
AU  - Ahad Bavili Tabrizi
AD  - Department of Medicinal Chemistry, Faculty of Pharmacy & Biotechnology Research 
      Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: 
      a.bavili@tbzmed.ac.ir.
FAU - Abdollahi, Ali
AU  - Abdollahi A
AD  - Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of 
      Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130409
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Aldehydes)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Aldehydes/*analysis
MH  - Chromatography, High Pressure Liquid
MH  - Injections
MH  - Liquid Phase Microextraction
MH  - Pharmaceutical Preparations/*analysis
MH  - Tobacco Smoke Pollution/*analysis
EDAT- 2013/05/07 06:00
MHDA- 2014/01/01 06:00
CRDT- 2013/05/07 06:00
PHST- 2012/12/20 00:00 [received]
PHST- 2013/03/14 00:00 [revised]
PHST- 2013/03/16 00:00 [accepted]
PHST- 2013/05/07 06:00 [entrez]
PHST- 2013/05/07 06:00 [pubmed]
PHST- 2014/01/01 06:00 [medline]
AID - S0304-3894(13)00221-5 [pii]
AID - 10.1016/j.jhazmat.2013.03.034 [doi]
PST - ppublish
SO  - J Hazard Mater. 2013 Jun 15;254-255:390-396. doi: 10.1016/j.jhazmat.2013.03.034. 
      Epub 2013 Apr 9.