PMID- 23645147
OWN - NLM
STAT- MEDLINE
DCOM- 20150306
LR  - 20211021
IS  - 1573-3521 (Electronic)
IS  - 0160-7715 (Print)
IS  - 0160-7715 (Linking)
VI  - 37
IP  - 4
DP  - 2014 Aug
TI  - The impact of age on outcomes in chronic obstructive pulmonary disease differs by 
      relationship status.
PG  - 654-63
LID - 10.1007/s10865-013-9516-7 [doi]
AB  - Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that can lead to 
      early-onset chronic obstructive pulmonary disease (COPD). The objective of this 
      study was to examine the impact of age on psychological and clinical outcomes 
      among individuals with AATD-associated COPD. 468 individuals with AATD-associated 
      COPD (age 32-84 at baseline) completed questionnaires at baseline, 1- and 2-year 
      follow-up. Age was examined as a predictor of depression, anxiety, health-related 
      quality of life, and breathlessness at all three time points using linear mixed 
      models. Age was associated with anxiety (b = -0.09, SE = 0.02, p < 0.001) and 
      health-related quality of life (b = -0.29, SE = 0.09, p < 0.001). Age also had a 
      statistically significant interaction with relationship status when predicting 
      depression, health-related quality of life, and breathlessness. Among individuals 
      who were single, younger age was associated with more symptoms of depression 
      (b = -0.08, SE = 0.03, p < 0.01), worse health-related quality of life 
      (b = -0.61, SE = 0.16, p < 0.001), and more breathlessness (b = -0.023, 
      SE = 0.009, p < 0.01) throughout the 2-year study. Age was not associated with 
      these three outcomes among individuals who were married/part of an unmarried 
      couple. Results suggest that individuals who develop a chronic illness at a young 
      age, particularly those who are single, may be more likely to have worse 
      psychological and clinical outcomes.
FAU - Holm, Kristen E
AU  - Holm KE
AD  - Department of Medicine, National Jewish Health, 1400 Jackson Street, Denver, CO, 
      80206, USA, holmk@njhealth.org.
FAU - Plaufcan, Melissa R
AU  - Plaufcan MR
FAU - Ford, Dee W
AU  - Ford DW
FAU - Sandhaus, Robert A
AU  - Sandhaus RA
FAU - Strand, Matthew
AU  - Strand M
FAU - Strange, Charlie
AU  - Strange C
FAU - Wamboldt, Frederick S
AU  - Wamboldt FS
LA  - eng
GR  - F32 HL083687/HL/NHLBI NIH HHS/United States
GR  - K23 HL091049/HL/NHLBI NIH HHS/United States
GR  - UL1 TR000154/TR/NCATS NIH HHS/United States
GR  - UL1 TR001082/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130504
PL  - United States
TA  - J Behav Med
JT  - Journal of behavioral medicine
JID - 7807105
RN  - alpha-1-Antitrypsin Deficiency, Autosomal Recessive
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology/*psychology
MH  - Anxiety/complications/diagnosis
MH  - Depression/complications/diagnosis
MH  - Dyspnea/complications
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic 
      Obstructive/complications/genetics/*psychology/*therapy
MH  - Quality of Life/psychology
MH  - Registries
MH  - Single Person/*psychology
MH  - Spouses/*psychology
MH  - Treatment Outcome
MH  - alpha 1-Antitrypsin Deficiency/complications/genetics/*psychology
PMC - PMC3772963
MID - NIHMS475986
EDAT- 2013/05/07 06:00
MHDA- 2015/03/07 06:00
PMCR- 2015/08/01
CRDT- 2013/05/07 06:00
PHST- 2012/08/24 00:00 [received]
PHST- 2013/04/25 00:00 [accepted]
PHST- 2013/05/07 06:00 [entrez]
PHST- 2013/05/07 06:00 [pubmed]
PHST- 2015/03/07 06:00 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - 10.1007/s10865-013-9516-7 [doi]
PST - ppublish
SO  - J Behav Med. 2014 Aug;37(4):654-63. doi: 10.1007/s10865-013-9516-7. Epub 2013 May 
      4.