PMID- 23646720
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20190715
IS  - 1533-4880 (Print)
IS  - 1533-4880 (Linking)
VI  - 13
IP  - 1
DP  - 2013 Jan
TI  - Time-course effects of intravenously administrated silica nanoparticles on blood 
      coagulation and endothelial function in rats.
PG  - 222-8
AB  - Among the most used inorganic nanomaterials, silica nanoparticles (NPs) have been 
      considered as either drug carriers or contrast agents. Though the distribution of 
      silica NPs via the circulation appears highly probable, to date, there are few 
      studies investigating the vascular effects of silica NPs in vivo. This study was 
      designed specifically to investigate whether silica NPs with intravenous 
      injection could lead to blood coagulation disorder and endothelium dysfunction in 
      vivo. The time-course effect of silica NPs on blood coagulation, oxidative stress 
      and the expression of soluble E-selectin (sE-selectin) and tissue factor (TF) in 
      the plasma of Sprague Dawley (SD) rats were presented. Our data showed that a 
      shortened prothrombin time (PT) was observed on 1 day after exposure to silica 
      NPs, while activated partial thromboplastin time (APTT) was not affected at any 
      time-points. After the post-injection respectively, the levels of fibrinogen 
      (Fbg) were increased by silica NPs from 1 day to 3 days, and returned to normal 
      value on the 7th day. Meanwhile, a sustained increase in the levels of TF and 
      sE-selectin was elicited by silica NPs during 7 days after the injection. In 
      addition, after 7 days of intravenously injection of silica NPs, the activities 
      of superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) in the plasma 
      of SD rats were decreased significantly, whereas the level of malondialdehyde 
      (MDA) was not changed obviously. In conclusion, intravenously administration of 
      silica NPs could shorten PT but not APTT increase TF and sE-selectin release and 
      reduce GSH-px and SOD activity in the plasma of SD rats, indicating exposure to 
      silica NPs could early activate coagulation cascade via the extrinsic pathway, 
      and may be dependent on endothelium dysfunction and oxidative stress.
FAU - Liu, Xin
AU  - Liu X
AD  - Shanghai Key Laboratory of Stomatology, Shanghai Biomaterials Research and 
      Testing Center, Ninth People's Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai 200023, China.
FAU - Sun, Jiao
AU  - Sun J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Animals
MH  - Blood Coagulation/drug effects/*physiology
MH  - Endothelium, Vascular/drug effects/*physiology
MH  - Injections, Intravenous
MH  - Male
MH  - Materials Testing
MH  - Nanoparticles/*administration & dosage
MH  - Prothrombin Time
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Silicon Dioxide/*administration & dosage
EDAT- 2013/05/08 06:00
MHDA- 2013/06/29 06:00
CRDT- 2013/05/08 06:00
PHST- 2013/05/08 06:00 [entrez]
PHST- 2013/05/08 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.1166/jnn.2013.6910 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2013 Jan;13(1):222-8. doi: 10.1166/jnn.2013.6910.