PMID- 23646949
OWN - NLM
STAT- MEDLINE
DCOM- 20140103
LR  - 20130507
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 81
IP  - 6
DP  - 2013 Jun
TI  - Peptide-binding motifs and characteristics for HLA -B*13:01 molecule.
PG  - 442-8
LID - 10.1111/tan.12114 [doi]
AB  - Trichloroethylene (TCE)-induced hypersensitivity dermatitis is one of the 
      critical occupational diseases among workers in China. Our previous studies have 
      identified a strong linkage between the disease and the HLA-B*13:01 allele. In 
      this study, we searched for peptides bound to the HLA-B*13:01 molecule; 57 
      HLA-B*13:01-bound peptides in total were identified and 54 peptides were used to 
      calculate frequency of amino acid residues to obtain binding motifs of 
      HLA-B*13:01 molecule. The results showed P2, P3, and P9 were the primary binding 
      anchor positions with the dominant anchor motifs of L, Q at P2, L at P9, D at P3. 
      HLA-B*13:01-bound peptides were identified for the first time in our research, 
      the results of which could contribute to the human leukocyte antigen 
      (HLA)-binding peptides database.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Zhang, J
AU  - Zhang J
AD  - Key laboratory of Chemical Safety and Health, Chinese Centre for Disease Control 
      and Prevention, National Institute for Occupational Health and Poison Control, 
      Chinese Centre for Disease Control and Prevention, Beijing, China.
FAU - Yang, H
AU  - Yang H
FAU - Li, H
AU  - Li H
FAU - Liu, F
AU  - Liu F
FAU - Jia, Q
AU  - Jia Q
FAU - Duan, H
AU  - Duan H
FAU - Niu, Y
AU  - Niu Y
FAU - Bin, P
AU  - Bin P
FAU - Zheng, Y
AU  - Zheng Y
FAU - Dai, Y
AU  - Dai Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B13 Antigen)
RN  - 0 (Peptide Fragments)
RN  - 290YE8AR51 (Trichloroethylene)
SB  - IM
MH  - Alleles
MH  - Binding Sites/genetics
MH  - Cell Line, Tumor
MH  - China
MH  - Computational Biology
MH  - Dermatitis, Occupational/etiology/*immunology
MH  - Genetic Predisposition to Disease
MH  - HLA-B13 Antigen/genetics/*metabolism
MH  - Humans
MH  - Peptide Fragments/genetics/isolation & purification/*metabolism
MH  - Polymorphism, Genetic
MH  - Protein Binding
MH  - Protein Structure, Tertiary
MH  - Trichloroethylene/adverse effects
EDAT- 2013/05/08 06:00
MHDA- 2014/01/05 06:00
CRDT- 2013/05/08 06:00
PHST- 2012/09/28 00:00 [received]
PHST- 2013/01/28 00:00 [revised]
PHST- 2013/03/18 00:00 [accepted]
PHST- 2013/05/08 06:00 [entrez]
PHST- 2013/05/08 06:00 [pubmed]
PHST- 2014/01/05 06:00 [medline]
AID - 10.1111/tan.12114 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Jun;81(6):442-8. doi: 10.1111/tan.12114.