PMID- 23647313
OWN - NLM
STAT- MEDLINE
DCOM- 20140515
LR  - 20171116
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 47
IP  - 11
DP  - 2013 Jun 4
TI  - Interaction of multiwalled carbon nanotubes with supported lipid bilayers and 
      vesicles as model biological membranes.
PG  - 5711-9
LID - 10.1021/es4002604 [doi]
AB  - The influence of solution chemistry on the kinetics and reversibility of the 
      deposition of multiwalled carbon nanotubes (MWNTs) on model biological membranes 
      was investigated using a quartz crystal microbalance with dissipation monitoring 
      (QCM-D). Supported lipid bilayers (SLBs) comprised of zwitterionic 
      1,2-dioleoyl-sn-glyero-3-phosphocholine (DOPC), as well as DOPC vesicles, were 
      used as model cell membranes. Under neutral pH conditions, the deposition 
      kinetics of MWNTs on SLBs increased with increasing electrolyte (NaCl and CaCl2) 
      concentrations. In the presence of NaCl, favorable deposition was not achieved 
      even at a concentration of 1 M, which is attributed to the presence of strong 
      repulsive hydration forces due to the highly hydrophilic headgroups of SLBs. 
      Conversely, favorable deposition was observed at CaCl2 concentrations above 0.5 
      mM when the charge of SLBs was reversed from negative to positive through the 
      binding of Ca(2+) cations to the exposed phosphate headgroups. Favorable nanotube 
      deposition was also observed at pH 2, at which the DOPC SLBs exhibited positive 
      surface charge, since the isoelectric point of DOPC is ca. 4. When MWNTs on SLBs 
      were rinsed with low ionic strength solutions at pH 7.3, only ca. 20% of 
      deposited nanotubes were released, indicating that nanotube deposition was mostly 
      irreversible. The deposition of MWNTs on DOPC vesicles under favorable deposition 
      conditions did not result in any detectable leakage of solution from the 
      vesicles, indicating that MWNTs did not severely disrupt the DOPC bilayers upon 
      attachment.
FAU - Yi, Peng
AU  - Yi P
AD  - Department of Geography and Environmental Engineering, Johns Hopkins University, 
      Baltimore, Maryland 21218-2686, United States.
FAU - Chen, Kai Loon
AU  - Chen KL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130522
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Cations)
RN  - 0 (Electrolytes)
RN  - 0 (Lipid Bilayers)
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Phosphatidylcholines)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - EDS2L3ODLV (1,2-oleoylphosphatidylcholine)
RN  - M4I0D6VV5M (Calcium Chloride)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Calcium/chemistry/metabolism
MH  - Calcium Chloride/chemistry
MH  - Cations
MH  - Cell Membrane/chemistry
MH  - Electrolytes/chemistry
MH  - Hydrogen-Ion Concentration
MH  - Kinetics
MH  - Lipid Bilayers/*chemistry
MH  - Nanotubes, Carbon/*chemistry
MH  - Phosphatidylcholines/*chemistry
MH  - Sodium Chloride/chemistry
EDAT- 2013/05/08 06:00
MHDA- 2014/05/16 06:00
CRDT- 2013/05/08 06:00
PHST- 2013/05/08 06:00 [entrez]
PHST- 2013/05/08 06:00 [pubmed]
PHST- 2014/05/16 06:00 [medline]
AID - 10.1021/es4002604 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2013 Jun 4;47(11):5711-9. doi: 10.1021/es4002604. Epub 2013 
      May 22.