PMID- 23647364
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20211021
IS  - 1530-0277 (Electronic)
IS  - 0145-6008 (Print)
IS  - 0145-6008 (Linking)
VI  - 37
IP  - 9
DP  - 2013 Sep
TI  - The role of acidemia in maternal binge alcohol-induced alterations in fetal bone 
      functional properties.
PG  - 1476-82
LID - 10.1111/acer.12118 [doi]
AB  - BACKGROUND: Heavy alcohol consumption during pregnancy negatively impacts the 
      physical growth of the fetus. Although the deleterious effects of alcohol 
      exposure during late gestation on fetal brain development are well documented, 
      little is known about the effect on fetal bone mechanical properties or the 
      underlying mechanisms. The purpose of this study was to investigate the effects 
      of late gestational chronic binge alcohol consumption and alcohol-induced 
      acidemia, a critical regulator of bone health, on functional properties of the 
      fetal skeletal system. METHODS: Suffolk ewes were mated and received intravenous 
      infusions of saline or alcohol (1.75 g/kg) over 1 hour on 3 consecutive days per 
      week followed by 4 days without treatment beginning on gestational day (GD) 109 
      and concluding on GD 132 (term = 147 days). The acidemia group was exposed to 
      increased inspired fractional concentrations of CO2 to closely mimic the 
      alcohol-induced decreases in maternal arterial pH seen in the alcohol group. 
      RESULTS: Fetal femurs and tibias from the alcohol and acidemia groups were ~3 to 
      7% shorter in length compared with the control groups (p < 0.05). Three-point 
      bending procedure demonstrated that fetal femoral ultimate strength (MPa) for the 
      alcohol group was decreased (p < 0.05) by ~24 and 29%, while the acidemia group 
      exhibited a similar decrease (p < 0.05) of ~32 and 37% compared with the normal 
      control and saline control groups, respectively. Bone extrinsic and intrinsic 
      mechanical properties including maximum breaking force (N) and normalized 
      breaking force (N/kg) of fetal bones from the alcohol and acidemia groups were 
      significantly decreased (p < 0.05) compared with both control groups. 
      CONCLUSIONS: We conclude that late gestational chronic binge alcohol exposure 
      reduces growth and impairs functional properties of the fetal skeletal system and 
      that the repeated episodes of alcohol-induced maternal acidemia may be at least 
      partially responsible for these effects.
CI  - Copyright (c) 2013 by the Research Society on Alcoholism.
FAU - Sawant, Onkar B
AU  - Sawant OB
AD  - Department of Veterinary Physiology and Pharmacology and Michael E. DeBakey 
      Institute , College of Veterinary Medicine and Biomedical Sciences, Texas A&M 
      University, College Station, Texas.
FAU - Ramadoss, Jayanth
AU  - Ramadoss J
FAU - Hogan, Harry A
AU  - Hogan HA
FAU - Washburn, Shannon E
AU  - Washburn SE
LA  - eng
GR  - R00 AA019446/AA/NIAAA NIH HHS/United States
GR  - R01 AA010940/AA/NIAAA NIH HHS/United States
GR  - K99 AA019446/AA/NIAAA NIH HHS/United States
GR  - K08 AA018166/AA/NIAAA NIH HHS/United States
GR  - AA19446/AA/NIAAA NIH HHS/United States
GR  - AA10940/AA/NIAAA NIH HHS/United States
GR  - K08AA18166/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130503
PL  - England
TA  - Alcohol Clin Exp Res
JT  - Alcoholism, clinical and experimental research
JID - 7707242
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Acidosis/*complications/metabolism/pathology
MH  - Animals
MH  - Binge Drinking/*complications/metabolism/pathology
MH  - Ethanol/toxicity
MH  - Female
MH  - Femur/*drug effects/growth & development/metabolism
MH  - Fetal Development/*drug effects/physiology
MH  - Pregnancy
MH  - Sheep
MH  - Tibia/*drug effects/growth & development/metabolism
PMC - PMC4183459
MID - NIHMS449105
OTO - NOTNLM
OT  - Acidemia
OT  - Bone Strength
OT  - Fetal Alcohol Spectrum Disorder
OT  - Pregnancy
OT  - Teratogenicity
EDAT- 2013/05/08 06:00
MHDA- 2014/04/23 06:00
PMCR- 2014/10/02
CRDT- 2013/05/08 06:00
PHST- 2012/12/07 00:00 [received]
PHST- 2013/01/31 00:00 [accepted]
PHST- 2013/05/08 06:00 [entrez]
PHST- 2013/05/08 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
PHST- 2014/10/02 00:00 [pmc-release]
AID - 10.1111/acer.12118 [doi]
PST - ppublish
SO  - Alcohol Clin Exp Res. 2013 Sep;37(9):1476-82. doi: 10.1111/acer.12118. Epub 2013 
      May 3.