PMID- 23648346
OWN - NLM
STAT- MEDLINE
DCOM- 20140811
LR  - 20130507
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 93
IP  - 2
DP  - 2013 Jan 8
TI  - [Surgical treatment for hypertrophic obstructive cardiomyopathy: a report of 118 
      cases].
PG  - 110-3
AB  - OBJECTIVE: To assess the clinical outcomes of transaortic extended septal 
      myectomy on early and midterm survival of patients with hypertrophic obstructive 
      cardiomyopathy (HOCM). METHODS: From October 2009 to April 2012, 118 consecutive 
      patients underwent extended Morrow's procedure for HOCM. There were 69 males and 
      49 females with an average age of (46 +/- 13) years. Their clinical data were 
      analyzed retrospectively. Preoperative transthoracic, intraoperative 
      transoesophageal and postoperative transthoracic echocardiography was performed 
      to assess septal thickness, left ventricular outflow tract (LVOT) gradient, 
      mitral valve function and systolic anterior motion (SAM) of anterior mitral valve 
      leaflet, etc. Concomitant surgical procedures were performed if other cardiac 
      diseases required surgical interventions. Follow-up study was carried out during 
      subsequent clinic visits at outpatient department and through telephone 
      interviews with patients and their relatives. RESULTS: The septal thickness was 
      (25 +/- 7) mm. SAM was detected in all. The in-hospital mortality was 0.8% (1/118) 
      since one patient died of multiple organs failure one week later. Postoperative 
      echocardiography demonstrated marked reduction in LVOT gradient (92 +/- 22 vs 13 +/- 
      10 mm Hg (1 mm Hg = 0.133 kPa), P = 0.000), New York Heart Association (NYHA) 
      class (2.9 +/- 0.6 vs 1.2 +/- 0.4, P = 0.000) and significant improvement in mitral 
      regurgitation. Concomitant surgical procedures were performed in 45 cases (38.1%, 
      all for preexisting conditions). Complications included complete atrioventricular 
      block (n = 3), first degree atrioventricular block (n = 6), complete left bundle 
      branch block (n = 51), intraventricular conduction delay or left anterior 
      division block (n = 26), transient renal dysfunction (n = 2) and 
      intra-aortic-balloon-pumping (n = 2). No other severe complication was observed. 
      During a follow-up period of 1 - 27 (7 +/- 6) months, there was no readmission or 
      death. All patients reported significant increase in physical ability and obvious 
      decrease in limiting symptoms. At the latest follow-up, the NYHA functional class 
      maintained grade I-II in all. And mitral regurgitation remained absent or mild. 
      CONCLUSION: Surgical procedure for HOCM patients is both safe and efficacious. It 
      provides an excellent relief of LVOT obstruction.
FAU - Luo, Ming-yao
AU  - Luo MY
AD  - State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center 
      for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Beijing 100037, China.
FAU - Wang, Shui-yun
AU  - Wang SY
FAU - Song, Yun-hu
AU  - Song YH
FAU - Yin, Chao-hua
AU  - Yin CH
FAU - Sun, Hong-tao
AU  - Sun HT
FAU - Sun, Xin
AU  - Sun X
FAU - Xu, Nan
AU  - Xu N
FAU - Xu, Jian-ping
AU  - Xu JP
FAU - Wang, Wei
AU  - Wang W
FAU - Hu, Sheng-shou
AU  - Hu SS
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Adult
MH  - *Cardiac Surgical Procedures
MH  - Cardiomyopathy, Hypertrophic/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Ventricular Outflow Obstruction/*surgery
EDAT- 2013/05/08 06:00
MHDA- 2014/08/12 06:00
CRDT- 2013/05/08 06:00
PHST- 2013/05/08 06:00 [entrez]
PHST- 2013/05/08 06:00 [pubmed]
PHST- 2014/08/12 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2013 Jan 8;93(2):110-3.