PMID- 23649513
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20211021
IS  - 1573-2576 (Electronic)
IS  - 0360-3997 (Linking)
VI  - 36
IP  - 5
DP  - 2013 Oct
TI  - Host modulation in rheumatoid arthritis patients with TNF blockers significantly 
      decreases biochemical parameters in periodontitis.
PG  - 1171-7
LID - 10.1007/s10753-013-9652-9 [doi]
AB  - The aim of this study was to evaluate the effects of host modulation therapy on 
      periodontal and biochemical parameters. Sixteen rheumatoid arthritis patients 
      newly scheduled for anti-tumour necrosis factor (TNF) therapy were screened for 
      30 days. Periodontal parameters (clinical attachment level, probing pocket depth, 
      bleeding on probing, plaque index and gingival index) as well as salivary and 
      gingival crevicular fluid (GCF), interleukin (IL)-1beta, IL-8 and monocyte 
      chemoattractant protein-1 (MCP-1) levels of the patients were evaluated at 
      baseline and on the 30th day of therapy. GCF volume, IL-1beta and IL-8 levels 
      (p = 0.007, p = 0.017 and p = 0.009, respectively) of the periodontitis patients 
      significantly decreased. Although there was a decrease in all these parameters in 
      healthy patients, it was below statistical significance. Salivary IL-8 and MCP-1 
      levels significantly decreased in periodontitis patients (p = 0.028 and 
      p = 0.013, respectively), but IL-1beta levels remained unchanged. These results 
      suggest that TNF blockers may significantly modify host response in terms of 
      biochemical parameters of the periodontium and may mask significant associations 
      such as those reported between periodontitis and rheumatoid arthritis.
FAU - Ustun, Kemal
AU  - Ustun K
AD  - Department of Periodontology, Faculty of Dentistry, Gaziantep University, 27310, 
      Gaziantep, Turkey, k_ustun@yahoo.com.
FAU - Erciyas, Kamile
AU  - Erciyas K
FAU - Kisacik, Bunyamin
AU  - Kisacik B
FAU - Sezer, Ufuk
AU  - Sezer U
FAU - Pehlivan, Yavuz
AU  - Pehlivan Y
FAU - Oztuzcu, Serdar
AU  - Oztuzcu S
FAU - Gundogar, Hasan
AU  - Gundogar H
FAU - Onat, Ahmet Mesut
AU  - Onat AM
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Inflammation
JT  - Inflammation
JID - 7600105
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/*metabolism
MH  - Chemokine CCL2/metabolism
MH  - Dental Plaque Index
MH  - Female
MH  - Gingival Crevicular Fluid/metabolism
MH  - Humans
MH  - Inflammation/metabolism/*therapy
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-8/metabolism
MH  - Male
MH  - Middle Aged
MH  - Periodontal Index
MH  - Periodontitis/metabolism/*therapy
MH  - Periodontium/chemistry
MH  - Saliva/metabolism
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
MH  - Young Adult
EDAT- 2013/05/08 06:00
MHDA- 2014/04/23 06:00
CRDT- 2013/05/08 06:00
PHST- 2013/05/08 06:00 [entrez]
PHST- 2013/05/08 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - 10.1007/s10753-013-9652-9 [doi]
PST - ppublish
SO  - Inflammation. 2013 Oct;36(5):1171-7. doi: 10.1007/s10753-013-9652-9.