PMID- 23649659
OWN - NLM
STAT- MEDLINE
DCOM- 20140618
LR  - 20220331
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 48
IP  - 3
DP  - 2013 Dec
TI  - Role of BDNF in central motor structures and motor diseases.
PG  - 783-93
LID - 10.1007/s12035-013-8466-y [doi]
AB  - Brain-derived neurotrophic factor (BDNF), belonging to the neurotrophic family of 
      growth factors, has a widespread distribution in the central and peripheral 
      nervous systems. In central motor structures including the motor cortex, 
      cerebellum, basal ganglia, and spinal cord, BDNF exerts both neurotrophic and 
      direct electrophysiological effects via a high-affinity tyrosine receptor kinase 
      B receptor and a common low-affinity p75 neurotrophin receptor. The underlying 
      signaling pathways mainly involve mitogen-activated protein kinase cascades, 
      phosphatidylinositol 3-kinase pathway, and phospholipase C-gamma pathway. The loss of 
      BDNF usually leads to neurodegeneration in these motor centers and eventually 
      results in several severe motor diseases, such as amyotrophic lateral sclerosis, 
      spinocerebellar ataxias, Parkinson's disease, Huntington's disease, as well as 
      vestibular syndrome. In this review, we summarize the recent understanding of 
      functions of BDNF in motor structures and suggest that BDNF may be a potent 
      candidate for the treatment of these neurodegenerative motor diseases.
FAU - He, Yan-Yan
AU  - He YY
AD  - Department of Biological Science and Technology and State Key Laboratory of 
      Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 
      Mailbox 426, 22 Hankou Road, Nanjing, 210093, China.
FAU - Zhang, Xiao-Yang
AU  - Zhang XY
FAU - Yung, Wing-Ho
AU  - Yung WH
FAU - Zhu, Jing-Ning
AU  - Zhu JN
FAU - Wang, Jian-Jun
AU  - Wang JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130507
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Electrophysiological Phenomena
MH  - Humans
MH  - Motor Neuron Disease/*metabolism/*pathology/physiopathology
MH  - Motor Neurons/*metabolism/*pathology
MH  - Signal Transduction
EDAT- 2013/05/08 06:00
MHDA- 2014/06/19 06:00
CRDT- 2013/05/08 06:00
PHST- 2013/03/14 00:00 [received]
PHST- 2013/04/22 00:00 [accepted]
PHST- 2013/05/08 06:00 [entrez]
PHST- 2013/05/08 06:00 [pubmed]
PHST- 2014/06/19 06:00 [medline]
AID - 10.1007/s12035-013-8466-y [doi]
PST - ppublish
SO  - Mol Neurobiol. 2013 Dec;48(3):783-93. doi: 10.1007/s12035-013-8466-y. Epub 2013 
      May 7.