PMID- 23649669
OWN - NLM
STAT- MEDLINE
DCOM- 20140306
LR  - 20211021
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 133
IP  - 10
DP  - 2013 Nov 15
TI  - Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular 
      carcinoma in the European prospective investigation into cancer and nutrition 
      study.
PG  - 2429-43
LID - 10.1002/ijc.28257 [doi]
AB  - Limited epidemiological evidence suggests a protective role for plant foods rich 
      in flavonoids and antioxidants in hepatocellular cancer (HCC) etiology. Our aim 
      was to prospectively investigate the association between dietary intake of 
      flavonoids, lignans and nonenzymatic antioxidant capacity (NEAC) and HCC risk. 
      Data from the European Prospective Investigation into Cancer and Nutrition (EPIC) 
      cohort including 477,206 subjects (29.8% male) recruited from ten Western 
      European countries, was analyzed. Flavonoid, lignan and NEAC intakes were 
      calculated using a compilation of existing food composition databases linked to 
      dietary information from validated dietary questionnaires. Dietary NEAC was based 
      on ferric reducing antioxidant capacity (FRAP) and total radical-trapping 
      antioxidant parameter (TRAP). Hepatitis B/C status was measured in a nested 
      case-control subset. During a mean follow-up of 11-years, 191 incident HCC cases 
      (66.5% men) were identified. Using Cox regression, multivariable adjusted models 
      showed a borderline nonsignificant association of HCC with total flavonoid intake 
      (highest versus lowest tertile, HR = 0.65, 95% CI: 0.40-1.04; p(trend) = 0.065), 
      but not with lignans. Among flavonoid subclasses, flavanols were inversely 
      associated with HCC risk (HR = 0.62, 95% CI: 0.39-0.99; p(trend) = 0.06). Dietary 
      NEAC was inversely associated with HCC (FRAP: HR 0.50, 95% CI: 0.31-0.81; 
      p(trend) = 0.001; TRAP: HR 0.49, 95% CI: 0.31-0.79; p(trend) = 0.002), but 
      statistical significance was lost after exclusion of the first 2 years of 
      follow-up. This study suggests that higher intake of dietary flavanols and 
      antioxidants may be associated with a reduced HCC risk.
CI  - Copyright (c) 2013 UICC.
FAU - Zamora-Ros, Raul
AU  - Zamora-Ros R
AD  - Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO), 
      Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain; Section of 
      Nutrition and Metabolism, International Agency for Research on Cancer (IARC), 
      Lyon, France.
FAU - Fedirko, Veronika
AU  - Fedirko V
FAU - Trichopoulou, Antonia
AU  - Trichopoulou A
FAU - Gonzalez, Carlos A
AU  - Gonzalez CA
FAU - Bamia, Christina
AU  - Bamia C
FAU - Trepo, Elisabeth
AU  - Trepo E
FAU - Nothlings, Ute
AU  - Nothlings U
FAU - Duarte-Salles, Talita
AU  - Duarte-Salles T
FAU - Serafini, Mauro
AU  - Serafini M
FAU - Bredsdorff, Lea
AU  - Bredsdorff L
FAU - Overvad, Kim
AU  - Overvad K
FAU - Tjonneland, Anne
AU  - Tjonneland A
FAU - Halkjaer, Jytte
AU  - Halkjaer J
FAU - Fagherazzi, Guy
AU  - Fagherazzi G
FAU - Perquier, Florence
AU  - Perquier F
FAU - Boutron-Ruault, Marie-Christine
AU  - Boutron-Ruault MC
FAU - Katzke, Verena
AU  - Katzke V
FAU - Lukanova, Annekatrin
AU  - Lukanova A
FAU - Floegel, Anna
AU  - Floegel A
FAU - Boeing, Heiner
AU  - Boeing H
FAU - Lagiou, Pagona
AU  - Lagiou P
FAU - Trichopoulos, Dimitrios
AU  - Trichopoulos D
FAU - Saieva, Calogero
AU  - Saieva C
FAU - Agnoli, Claudia
AU  - Agnoli C
FAU - Mattiello, Amalia
AU  - Mattiello A
FAU - Tumino, Rosario
AU  - Tumino R
FAU - Sacerdote, Carlotta
AU  - Sacerdote C
FAU - Bueno-de-Mesquita, H Bas
AU  - Bueno-de-Mesquita HB
FAU - Peeters, Petra H M
AU  - Peeters PH
FAU - Weiderpass, Elisabete
AU  - Weiderpass E
FAU - Engeset, Dagrun
AU  - Engeset D
FAU - Skeie, Guri
AU  - Skeie G
FAU - Arguelles, Marcial Vicente
AU  - Arguelles MV
FAU - Molina-Montes, Esther
AU  - Molina-Montes E
FAU - Dorronsoro, Miren
AU  - Dorronsoro M
FAU - Tormo, Maria Jose
AU  - Tormo MJ
FAU - Ardanaz, Eva
AU  - Ardanaz E
FAU - Ericson, Ulrika
AU  - Ericson U
FAU - Sonestedt, Emily
AU  - Sonestedt E
FAU - Sund, Malin
AU  - Sund M
FAU - Landberg, Rikard
AU  - Landberg R
FAU - Khaw, Kay-Tee
AU  - Khaw KT
FAU - Wareham, Nicholas J
AU  - Wareham NJ
FAU - Crowe, Francesca L
AU  - Crowe FL
FAU - Riboli, Elio
AU  - Riboli E
FAU - Jenab, Mazda
AU  - Jenab M
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - BHF_/British Heart Foundation/United Kingdom
GR  - DH_/Department of Health/United Kingdom
GR  - G1000143/MRC_/Medical Research Council/United Kingdom
GR  - 14136/CRUK_/Cancer Research UK/United Kingdom
GR  - G0401527/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130604
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
RN  - 0 (Lignans)
SB  - IM
MH  - Antioxidants/*administration & dosage/metabolism
MH  - Carcinoma, Hepatocellular/epidemiology/*etiology
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diet/statistics & numerical data
MH  - Europe/epidemiology
MH  - Feeding Behavior
MH  - Female
MH  - Flavonoids/*administration & dosage/metabolism
MH  - Follow-Up Studies
MH  - Humans
MH  - Lignans/*administration & dosage/metabolism
MH  - Liver Neoplasms/*epidemiology/etiology
MH  - Male
MH  - Middle Aged
MH  - Nutritional Status
MH  - Prospective Studies
MH  - Risk
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - EPIC
OT  - antioxidant capacity
OT  - dietary intake
OT  - flavonoids
OT  - hepatocellular carcinoma
OT  - lignans
EDAT- 2013/05/08 06:00
MHDA- 2014/03/07 06:00
CRDT- 2013/05/08 06:00
PHST- 2013/02/19 00:00 [received]
PHST- 2013/04/16 00:00 [accepted]
PHST- 2013/05/08 06:00 [entrez]
PHST- 2013/05/08 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1002/ijc.28257 [doi]
PST - ppublish
SO  - Int J Cancer. 2013 Nov 15;133(10):2429-43. doi: 10.1002/ijc.28257. Epub 2013 Jun 
      4.