PMID- 23650078
OWN - NLM
STAT- MEDLINE
DCOM- 20151009
LR  - 20211021
IS  - 1522-2594 (Electronic)
IS  - 0740-3194 (Linking)
VI  - 71
IP  - 3
DP  - 2014 Mar
TI  - Combined saturation/inversion recovery sequences for improved evaluation of scar 
      and diffuse fibrosis in patients with arrhythmia or heart rate variability.
PG  - 1024-34
LID - 10.1002/mrm.24761 [doi]
AB  - PURPOSE: To develop arrhythmia-insensitive inversion recovery sequences for 
      improved visualization of myocardial scar and quantification of diffuse fibrosis. 
      METHODS: A novel preparation pre-pulse, called saturation pulse prepared 
      heart-rate-independent inversion recovery, is introduced, which consists of a 
      combination of saturation and inversion pulses to remove the magnetization 
      history in each heartbeat in late gadolinium enhancement (LGE) imaging and 
      eliminate the need for rest periods in T1 mapping. The proposed LGE and T1 
      mapping sequences were evaluated against conventional LGE and modified 
      Look-Locker inversion sequences using numerical simulations, phantom and imaging 
      in healthy subjects and patients with suspected or known cardiovascular disease. 
      RESULTS: Simulations and phantom experiments show that the saturation pulse 
      prepared heart-rate-independent inversion recovery pre-pulse in LGE reduces 
      ghosting artifacts and results in perfect nulling of the healthy myocardium in 
      the presence of arrhythmia. In T1 mapping, saturation pulse prepared 
      heart-rate-independent inversion recovery results in (a) reduced scan time (17 
      vs. 9 heartbeats), (b) insensitivity to heart rate for long T1, and (c) increased 
      signal homogeneity for short T1. LGE images in a patient in atrial fibrillation 
      during the scan show improved myocardial nulling. In vivo T1 maps demonstrate 
      increased signal homogeneity in blood pools and myocardium. CONCLUSION: The 
      proposed sequences are insensitive to heart rate variability, yield improved LGE 
      images in the presence of arrhythmias, as well as T1 mapping with shorter scan 
      times.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Weingartner, Sebastian
AU  - Weingartner S
AD  - Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical 
      School, Boston, Massachusetts, USA; Computer Assisted Clinical Medicine, 
      University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
FAU - Akcakaya, Mehmet
AU  - Akcakaya M
FAU - Basha, Tamer
AU  - Basha T
FAU - Kissinger, Kraig V
AU  - Kissinger KV
FAU - Goddu, Beth
AU  - Goddu B
FAU - Berg, Sophie
AU  - Berg S
FAU - Manning, Warren J
AU  - Manning WJ
FAU - Nezafat, Reza
AU  - Nezafat R
LA  - eng
GR  - R01 EB008743/EB/NIBIB NIH HHS/United States
GR  - R01EB008743-01A2/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
SB  - IM
MH  - Adult
MH  - *Algorithms
MH  - Atrial Fibrillation/complications/*pathology
MH  - Fibrosis
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Stunning/etiology/*pathology
MH  - Myocardium/*pathology
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2013/05/08 06:00
MHDA- 2015/10/10 06:00
CRDT- 2013/05/08 06:00
PHST- 2013/05/08 06:00 [entrez]
PHST- 2013/05/08 06:00 [pubmed]
PHST- 2015/10/10 06:00 [medline]
AID - 10.1002/mrm.24761 [doi]
PST - ppublish
SO  - Magn Reson Med. 2014 Mar;71(3):1024-34. doi: 10.1002/mrm.24761.