PMID- 23650992
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20181202
IS  - 1521-0758 (Electronic)
IS  - 0191-3123 (Linking)
VI  - 37
IP  - 3
DP  - 2013 May
TI  - Comparison of the ultrastructural and immunophenotypic characteristics of human 
      umbilical cord-derived mesenchymal stromal cells and in situ cells in Wharton's 
      jelly.
PG  - 196-203
LID - 10.3109/01913123.2013.772268 [doi]
AB  - The umbilical cord contains mucinous connective tissue, called Wharton's jelly. 
      It consists of stromal cells, collagen fibers, and amorphous ground substances 
      composed of proteoglycan. Recently, these stromal cells have been redefined as a 
      new cell therapy source, named human umbilical cord-derived mesenchymal stromal 
      cells (hUCMSCs). However, there are few studies on the ultrastructural features 
      and immune-phenotypic characteristics of isolated hUCMSCs and comparisons with 
      the cells found in original cord tissues. In this study, the authors describe and 
      compare the phenotypic characteristics of hUCMSCs with cells in the umbilical 
      cord in order to know the kinds of cells and ultrastructural changes. Isolated 
      hUCMSCs showed similar ultrastructure with few structural differences from in 
      situ stromal cells, and they are relatively homogenous and well-developed 
      mesenchymal cells that demonstrate a myofibroblastic phenotype.
FAU - Ryu, Young-joon
AU  - Ryu YJ
AD  - Department of Pathology, University of Ulsan College of Medicine, Asan Medical 
      Center, Seoul, Korea.
FAU - Seol, Hyang Sook
AU  - Seol HS
FAU - Cho, Tae Jun
AU  - Cho TJ
FAU - Kwon, Tae Jung
AU  - Kwon TJ
FAU - Jang, Se Jin
AU  - Jang SJ
FAU - Cho, Jaejin
AU  - Cho J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Ultrastruct Pathol
JT  - Ultrastructural pathology
JID - 8002867
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/analysis
MH  - Cell Separation/methods
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - *Immunophenotyping
MH  - Mesenchymal Stem Cells/*immunology/*ultrastructure
MH  - Microscopy, Electron, Transmission
MH  - Myofibroblasts/immunology/ultrastructure
MH  - Phenotype
MH  - Pregnancy
MH  - Umbilical Cord/cytology/*immunology/*ultrastructure
MH  - Wharton Jelly/cytology/*immunology/*ultrastructure
EDAT- 2013/05/09 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/05/09 06:00
PHST- 2013/05/09 06:00 [entrez]
PHST- 2013/05/09 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.3109/01913123.2013.772268 [doi]
PST - ppublish
SO  - Ultrastruct Pathol. 2013 May;37(3):196-203. doi: 10.3109/01913123.2013.772268.