PMID- 23651511
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 13
IP  - 6
DP  - 2013 Jun
TI  - Amnion-derived multipotent progenitor cells support allograft tolerance 
      induction.
PG  - 1416-28
LID - 10.1111/ajt.12252 [doi]
AB  - Donor-specific immunological tolerance using high doses of bone marrow cells 
      (BMCs) has been demonstrated in mixed chimerism-based tolerance induction 
      protocols; however, the development of graft versus host disease remains a risk. 
      Here, we demonstrate that the co-infusion of limited numbers of donor 
      unfractionated BMCs with human amnion-derived multipotent progenitor cells (AMPs) 
      7 days post-allograft transplantation facilitates macrochimerism induction and 
      graft tolerance in a mouse skin transplantation model. AMPs + BMCs co-infusion 
      with minimal conditioning led to stable, mixed, multilineage lymphoid and myeloid 
      macrochimerism, deletion of donor-reactive T cells, expansion of 
      CD4(+)CD25(+)Foxp3(+) regulatory T cells (T(regs)) and long-term allograft 
      survival (>300 days). Based on these findings, we speculate that AMPs maybe a 
      pro-tolerogenic cellular therapeutic that could have clinical efficacy for both 
      solid organ and hematopoietic stem cell transplant applications.
CI  - (c) Copyright 2013 The American Society of Transplantation and the American Society 
      of Transplant Surgeons.
FAU - Anam, K
AU  - Anam K
AD  - Department of Regenerative Medicine, Operational and Undersea Medicine 
      Directorate at the Naval Medical Research Center, Silver Spring, MD, USA.
FAU - Lazdun, Y
AU  - Lazdun Y
FAU - Davis, P M
AU  - Davis PM
FAU - Banas, R A
AU  - Banas RA
FAU - Elster, E A
AU  - Elster EA
FAU - Davis, T A
AU  - Davis TA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130507
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
SB  - IM
MH  - Amnion/*cytology
MH  - Animals
MH  - Disease Models, Animal
MH  - Female
MH  - Graft Survival/*immunology
MH  - *Immunity, Cellular
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Multipotent Stem Cells/cytology/immunology/*transplantation
MH  - Skin Transplantation/*immunology
MH  - Transplantation Conditioning/methods
MH  - Transplantation Tolerance/*immunology
MH  - Transplantation, Homologous
EDAT- 2013/05/09 06:00
MHDA- 2013/10/30 06:00
CRDT- 2013/05/09 06:00
PHST- 2012/07/23 00:00 [received]
PHST- 2013/02/11 00:00 [revised]
PHST- 2013/03/10 00:00 [accepted]
PHST- 2013/05/09 06:00 [entrez]
PHST- 2013/05/09 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - S1600-6135(22)25969-3 [pii]
AID - 10.1111/ajt.12252 [doi]
PST - ppublish
SO  - Am J Transplant. 2013 Jun;13(6):1416-28. doi: 10.1111/ajt.12252. Epub 2013 May 7.