PMID- 23651634
OWN - NLM
STAT- MEDLINE
DCOM- 20140219
LR  - 20220318
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 121
IP  - 7
DP  - 2013 Jul
TI  - Evaluation of the association between persistent organic pollutants (POPs) and 
      diabetes in epidemiological studies: a national toxicology program workshop 
      review.
PG  - 774-83
LID - 10.1289/ehp.1205502 [doi]
AB  - BACKGROUND: Diabetes is a major threat to public health in the United States and 
      worldwide. Understanding the role of environmental chemicals in the development 
      or progression of diabetes is an emerging issue in environmental health. 
      OBJECTIVE: We assessed the epidemiologic literature for evidence of associations 
      between persistent organic pollutants (POPs) and type 2 diabetes. METHODS: Using 
      a PubMed search and reference lists from relevant studies or review articles, we 
      identified 72 epidemiological studies that investigated associations of 
      persistent organic pollutants (POPs) with diabetes. We evaluated these studies 
      for consistency, strengths and weaknesses of study design (including power and 
      statistical methods), clinical diagnosis, exposure assessment, study population 
      characteristics, and identification of data gaps and areas for future research. 
      CONCLUSIONS: Heterogeneity of the studies precluded conducting a meta-analysis, 
      but the overall evidence is sufficient for a positive association of some 
      organochlorine POPs with type 2 diabetes. Collectively, these data are not 
      sufficient to establish causality. Initial data mining revealed that the 
      strongest positive correlation of diabetes with POPs occurred with organochlorine 
      compounds, such as trans-nonachlor, dichlorodiphenyldichloroethylene (DDE), 
      polychlorinated biphenyls (PCBs), and dioxins and dioxin-like chemicals. There is 
      less indication of an association between other nonorganochlorine POPs, such as 
      perfluoroalkyl acids and brominated compounds, and type 2 diabetes. Experimental 
      data are needed to confirm the causality of these POPs, which will shed new light 
      on the pathogenesis of diabetes. This new information should be considered by 
      governmental bodies involved in the regulation of environmental contaminants.
FAU - Taylor, Kyla W
AU  - Taylor KW
AD  - Office of Health Assessment and Translation, Division of the National Toxicology 
      Program, National Institute of Environmental Health Sciences, National Institutes 
      of Health, Department of Health and Human Services, Research Triangle Park, North 
      Carolina 27709 , USA. taylorkw@niehs.nih.gov
FAU - Novak, Raymond F
AU  - Novak RF
FAU - Anderson, Henry A
AU  - Anderson HA
FAU - Birnbaum, Linda S
AU  - Birnbaum LS
FAU - Blystone, Chad
AU  - Blystone C
FAU - Devito, Michael
AU  - Devito M
FAU - Jacobs, David
AU  - Jacobs D
FAU - Kohrle, Josef
AU  - Kohrle J
FAU - Lee, Duk-Hee
AU  - Lee DH
FAU - Rylander, Lars
AU  - Rylander L
FAU - Rignell-Hydbom, Anna
AU  - Rignell-Hydbom A
FAU - Tornero-Velez, Rogelio
AU  - Tornero-Velez R
FAU - Turyk, Mary E
AU  - Turyk ME
FAU - Boyles, Abee L
AU  - Boyles AL
FAU - Thayer, Kristina A
AU  - Thayer KA
FAU - Lind, Lars
AU  - Lind L
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
DEP - 20130507
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/chemically induced/*epidemiology
MH  - *Environmental Exposure
MH  - Environmental Pollutants/analysis/*toxicity
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis/toxicity
MH  - Mice
MH  - Obesity/chemically induced/epidemiology
MH  - Rats
PMC - PMC3701910
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2013/05/09 06:00
MHDA- 2014/02/20 06:00
PMCR- 2013/07/01
CRDT- 2013/05/09 06:00
PHST- 2012/05/21 00:00 [received]
PHST- 2013/05/01 00:00 [accepted]
PHST- 2013/05/09 06:00 [entrez]
PHST- 2013/05/09 06:00 [pubmed]
PHST- 2014/02/20 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - ehp.1205502 [pii]
AID - 10.1289/ehp.1205502 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2013 Jul;121(7):774-83. doi: 10.1289/ehp.1205502. Epub 
      2013 May 7.