PMID- 23652060
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20220408
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 126
IP  - 9
DP  - 2013
TI  - Factors potentially affecting the function of kidney grafts.
PG  - 1738-42
AB  - BACKGROUND: Donor and recipient risk factors on graft function have been well 
      characterized. The contribution of demographic factors, such as age, gender, and 
      other potential factors of donor and recipient at the time of transplantation on 
      the function of a graft is much less well understood. In this study, we analyzed 
      the effects of factors such as age, gender, etc., on the short-term and long-term 
      graft function in kidney transplant recipients from living donor. METHODS: A 
      total of 335 living donors and their recipients, who had kidney transplantation 
      in our center from May 2004 to December 2009, were included. Serum creatinine 
      level was used as the assessment criterion (serum creatinine level lower than 115 
      mmol/L is normal). Factors related to graft function such as age, gender, blood 
      relation by consanguinity, human leukocyte antigen (HLA) mismatch, ABO type, 
      etc., were analyzed separately. RESULTS: Donor age is the key factor affecting 
      both the short-term and long-term function of a grafted kidney from a living 
      donor. The group with donors younger than 48 years showed the best kidney 
      function post transplantation. Match of gender and age is another important 
      factor that influences the function of grafted kidney from a living donor. The 
      older donor to younger recipient group had the worst outcome after kidney 
      transplantation. After 36 months post transplantation, female donor to male 
      recipient group had worse kidney function compared to other groups. We also found 
      that calcinerin inhibitor used in the maintenance period may influence the 
      function of a grafted kidney. No significant statistical differences were found 
      in consanguinity, blood type, and mismatch of HLA. CONCLUSIONS: Donor age is an 
      important factor affecting the function of a grafted kidney from a living donor. 
      We also recommend taking nephron, immunology factor, infection, and demographic 
      information all into consideration when assessing the outcome of kidney 
      transplantation.
FAU - Lin, Jun
AU  - Lin J
AD  - Department of Urology, Beijing Friendship Hospital, Beijing 100050, China.
FAU - Zheng, Xin
AU  - Zheng X
FAU - Xie, Ze-lin
AU  - Xie ZL
FAU - Sun, Wen
AU  - Sun W
FAU - Zhang, Lei
AU  - Zhang L
FAU - Tian, Ye
AU  - Tian Y
FAU - Guo, Yu-wen
AU  - Guo YW
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aging
MH  - Child
MH  - Female
MH  - Histocompatibility Testing
MH  - Humans
MH  - Kidney/physiopathology
MH  - *Kidney Transplantation
MH  - Living Donors
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
EDAT- 2013/05/09 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/05/09 06:00
PHST- 2013/05/09 06:00 [entrez]
PHST- 2013/05/09 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2013;126(9):1738-42.